TOP2B

gene product
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]
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130 antibodies from 23 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Bethyl Laboratories, Inc.
3 antibodies
antibodies-online
45 antibodies
Novus Biologicals
7 antibodies
Proteintech Group
1 antibody
Acris Antibodies GmbH
6 antibodies
GeneTex
4 antibodies
Atlas Antibodies
1 antibody
Santa Cruz Biotechnology
1 antibody
Aviva Systems Biology
3 antibodies
Thermo Fisher Scientific Pierce
4 antibodies
LifeSpan BioSciences, Inc.
18 antibodies
Abnova Corporation
6 antibodies
R&D Systems
2 antibodies
RabMAbs
2 antibodies
Creative Biomart
13 antibodies
Spring Bioscience
4 antibodies
Abbiotec
1 antibody
Bioworld Technology, Inc
1 antibody
Sigma-Aldrich
2 antibodies
EMD Millipore
1 antibody
GenWay
2 antibodies
United States Biological
2 antibodies
RayBiotech, Inc.
1 antibody