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- References [175]
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- Western blot [8]
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- Product number
- GTX627408 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX627408, RRID:AB_11174761
- Product name
- GAPDH antibody [GT239]
- Antibody type
- Monoclonal
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- Human, Mouse, Rat, Drosophila, Porcine, Simian, Yeast, Zebrafish
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- Mouse
Submitted references Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.
High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells.
LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing.
Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation: The Potential Mechanism Underlying Augmentation of β-Amyloid Pathology by Type 2 Diabetes Mellitus.
Quantitative Proteomics of the Mitotic Chromosome Scaffold Reveals the Association of BAZ1B with Chromosomal Axes.
Metformin Treatment Suppresses Melanoma Cell Growth and Motility Through Modulation of microRNA Expression.
Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes.
Regulation of Hepatitis C Virus Infection by Cellular Retinoic Acid Binding Proteins through the Modulation of Lipid Droplet Abundance.
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.
Soluble Factors from Human Olfactory Neural Stem/Progenitor Cells Influence the Fate Decisions of Hippocampal Neural Precursor Cells.
The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1.
Spinal RNF20-Mediated Histone H2B Monoubiquitylation Regulates mGluR5 Transcription for Neuropathic Allodynia.
DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing.
Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells.
Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection.
Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy.
Androgens modulate chronic intermittent hypoxia effects on brain and behavior.
MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.
Transient stretch induces cytoskeletal fluidization through the severing action of cofilin.
The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome.
Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice.
IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma.
Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets.
Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence.
Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.
A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.
Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P2 during receptor-mediated endocytosis in yeast.
Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma.
Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition.
MicroRNA-324-5p regulates stemness, pathogenesis and sensitivity to bortezomib in multiple myeloma cells by targeting hedgehog signaling.
Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein Is Crucial for Production of Infectious Virus Particles.
Bortezomib improves adoptive carbonic anhydrase IX‑specific chimeric antigen receptor‑modified NK92 cell therapy in mouse models of human renal cell carcinoma.
Deletion of the Mitochondrial Complex-IV Cofactor Heme A:Farnesyltransferase Causes Focal Segmental Glomerulosclerosis and Interferon Response.
Mechanisms of Matrix-Induced Chemoresistance of Breast Cancer Cells-Deciphering Novel Potential Targets for a Cell Sensitization.
BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling.
PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease.
Somatic mutations activating Wiskott-Aldrich syndrome protein concomitant with RAS pathway mutations in juvenile myelomonocytic leukemia patients.
9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1, 2-c]quinolin-11-one (BPIQ), A Quinoline Derivative Inhibits Human Hepatocellular Carcinoma Cells by Inducing ER Stress and Apoptosis.
Using Histone Deacetylase Inhibitors to Analyze the Relevance of HDACs for Translation.
ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency.
PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.
FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.
Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV Receptor.
MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation.
Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
ER phospholipid composition modulates lipogenesis during feeding and in obesity.
Denervation-related alterations and biological activity of miRNAs contained in exosomes released by skeletal muscle fibers.
MicroRNA-212/ABCG2-axis contributes to development of imatinib-resistance in leukemic cells.
FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.
The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons.
Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation.
Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.
Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure.
Obesity induces pro-inflammatory B cells and impairs B cell function in old mice.
TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.
The putative involvement of actin-binding proteins and cytoskeleton proteins in pathological mechanisms of ketamine cystitis-Revealed by a prospective pilot study using proteomic approaches.
Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.
Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice.
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease.
Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13.
DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cells.
Presence of Androgen Receptor Variant in Neuronal Lipid Rafts.
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway.
Generation of ribosome imprinted polymers for sensitive detection of translational responses.
The drebrin/EB3 pathway drives invasive activity in prostate cancer.
Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin.
Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.
Excavatolide B Attenuates Rheumatoid Arthritis through the Inhibition of Osteoclastogenesis.
A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.
Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma.
Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation.
Platelet activating factor-induced expression of p21 is correlated with histone acetylation.
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.
Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.
Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells.
Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation.
VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation.
Dysregulation of the MEK/ERK/MNK1 signalling cascade by middle T antigen of the trichoydsplasia spinulosa polyomavirus.
Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.
Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals.
MiR-30a-5p Inhibits Epithelial-to-Mesenchymal Transition and Upregulates Expression of Tight Junction Protein Claudin-5 in Human Upper Tract Urothelial Carcinoma Cells.
Molecular mechanisms supporting a pathogenic role for human polyomavirus 6 small T antigen: Protein phosphatase 2A targeting and MAPK cascade activation.
Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.
Activation-Dependent TRAF3 Exon 8 Alternative Splicing Is Controlled by CELF2 and hnRNP C Binding to an Upstream Intronic Element.
A Subpopulation of the K562 Cells Are Killed by Curcumin Treatment after G2/M Arrest and Mitotic Catastrophe.
c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells.
Mycotoxin Patulin Suppresses Innate Immune Responses by Mitochondrial Dysfunction and p62/Sequestosome-1-dependent Mitophagy.
Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells.
Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON.
Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration.
Targeting the ERK pathway for the treatment of Cushing's disease.
SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance.
Expression of glycine receptors and gephyrin in rat medial vestibular nuclei and flocculi following unilateral labyrinthectomy.
Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines.
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis.
Chemotherapy-Induced Inflammatory Gene Signature and Protumorigenic Phenotype in Pancreatic CAFs via Stress-Associated MAPK.
Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells.
FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes.
CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.
Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
KLF4 deletion alters gastric cell lineage and induces MUC2 expression.
Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.
Arm Selection Preference of MicroRNA-193a Varies in Breast Cancer.
Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure.
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
An essential receptor for adeno-associated virus infection.
Sec16 alternative splicing dynamically controls COPII transport efficiency.
Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins.
Crystal structures of APOBEC3G N-domain alone and its complex with DNA.
Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion.
Efficient Mitochondrial Genome Editing by CRISPR/Cas9.
PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes.
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.
CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer.
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.
SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.
β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration.
The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing.
Roles of Phosphorylation of the Nucleocapsid Protein of Mumps Virus in Regulating Viral RNA Transcription and Replication.
Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.
BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9.
The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis.
Retbindin is an extracellular riboflavin-binding protein found at the photoreceptor/retinal pigment epithelium interface.
Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.
DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance.
Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration.
Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade.
Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5.
The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage.
The histone deacetylase inhibitor, Vorinostat, represses hypoxia inducible factor 1 alpha expression through translational inhibition.
Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
miR-7 and miR-153 protect neurons against MPP(+)-induced cell death via upregulation of mTOR pathway.
Andrographolide induces apoptosis of C6 glioma cells via the ERK-p53-caspase 7-PARP pathway.
The effect of sesamin on airway fibrosis in vitro and in vivo.
Tumor necrosis factor-alpha mediates activation of NF-κB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways.
Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation.
Lentiviral delivery of PPARγ shRNA alters the balance of osteogenesis and adipogenesis, improving bone microarchitecture.
Single-cell Western blotting after whole-cell imaging to assess cancer chemotherapeutic response.
GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment.
FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks.
Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon.
Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer.
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.
CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer.
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
CtIP mediates replication fork recovery in a FANCD2-regulated manner.
Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy.
Nrf2 protects against TWEAK-mediated skeletal muscle wasting.
Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake.
Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse.
Decorin differentially modulates the activity of insulin receptor isoform A ligands.
Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death.
Zfp423 binds autoregulatory sites in p19 cell culture model.
Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
SIL1 mutations and clinical spectrum in patients with Marinesco-Sjogren syndrome.
Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA.
Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin.
Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling.
Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy.
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, Birsoy K
Nature 2019 Mar;567(7746):118-122
Nature 2019 Mar;567(7746):118-122
The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.
Rodrigues ACZ, Messi ML, Wang ZM, Abba MC, Pereyra A, Birbrair A, Zhang T, O'Meara M, Kwan P, Lopez EIS, Willis MS, Mintz A, Files DC, Furdui C, Oppenheim RW, Delbono O
Acta physiologica (Oxford, England) 2019 Mar;225(3):e13195
Acta physiologica (Oxford, England) 2019 Mar;225(3):e13195
High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells.
Hu CM, Tien SC, Hsieh PK, Jeng YM, Chang MC, Chang YT, Chen YJ, Chen YJ, Lee EYP, Lee WH
Cell metabolism 2019 Mar 4;
Cell metabolism 2019 Mar 4;
LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing.
Brifault C, Kwon H, Campana WM, Gonias SL
Glia 2019 Jun;67(6):1210-1224
Glia 2019 Jun;67(6):1210-1224
Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation: The Potential Mechanism Underlying Augmentation of β-Amyloid Pathology by Type 2 Diabetes Mellitus.
Takeuchi S, Ueda N, Suzuki K, Shimozawa N, Yasutomi Y, Kimura N
The American journal of pathology 2019 Feb;189(2):391-404
The American journal of pathology 2019 Feb;189(2):391-404
Quantitative Proteomics of the Mitotic Chromosome Scaffold Reveals the Association of BAZ1B with Chromosomal Axes.
Ohta S, Taniguchi T, Sato N, Hamada M, Taniguchi H, Rappsilber J
Molecular & cellular proteomics : MCP 2019 Feb;18(2):169-181
Molecular & cellular proteomics : MCP 2019 Feb;18(2):169-181
Metformin Treatment Suppresses Melanoma Cell Growth and Motility Through Modulation of microRNA Expression.
Tseng HW, Li SC, Tsai KW
Cancers 2019 Feb 11;11(2)
Cancers 2019 Feb 11;11(2)
Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes.
Chou CK, Huang HW, Yang CF, Dahms HU, Liang SS, Wang TN, Kuo PL, Hsi E, Tsai EM, Chiu CC
Environmental toxicology 2019 Apr;34(4):401-414
Environmental toxicology 2019 Apr;34(4):401-414
Regulation of Hepatitis C Virus Infection by Cellular Retinoic Acid Binding Proteins through the Modulation of Lipid Droplet Abundance.
Bang BR, Li M, Tsai KN, Aoyagi H, Lee SA, Machida K, Aizaki H, Jung JU, Ou JJ, Saito T
Journal of virology 2019 Apr 15;93(8)
Journal of virology 2019 Apr 15;93(8)
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
Zhang N, Pati D
Journal of cancer science & therapy 2018;10(3)
Journal of cancer science & therapy 2018;10(3)
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.
Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J
Cell reports 2018 Sep 18;24(12):3312-3323.e5
Cell reports 2018 Sep 18;24(12):3312-3323.e5
Soluble Factors from Human Olfactory Neural Stem/Progenitor Cells Influence the Fate Decisions of Hippocampal Neural Precursor Cells.
Gómez-Virgilio L, Ramírez-Rodríguez GB, Sánchez-Torres C, Ortiz-López L, Meraz-Ríos MA
Molecular neurobiology 2018 Oct;55(10):8014-8037
Molecular neurobiology 2018 Oct;55(10):8014-8037
The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1.
Kretschmer J, Rao H, Hackert P, Sloan KE, Höbartner C, Bohnsack MT
RNA (New York, N.Y.) 2018 Oct;24(10):1339-1350
RNA (New York, N.Y.) 2018 Oct;24(10):1339-1350
Spinal RNF20-Mediated Histone H2B Monoubiquitylation Regulates mGluR5 Transcription for Neuropathic Allodynia.
Lai CY, Hsieh MC, Ho YC, Wang HH, Chou D, Wen YC, Yang PS, Cheng JK, Peng HY
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Oct 24;38(43):9160-9174
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Oct 24;38(43):9160-9174
DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing.
Chakraborty P, Huang JTJ, Hiom K
Nature communications 2018 Oct 19;9(1):4346
Nature communications 2018 Oct 19;9(1):4346
Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells.
Ponert JM, Gockel LM, Henze S, Schlesinger M
Molecules (Basel, Switzerland) 2018 Oct 19;23(10)
Molecules (Basel, Switzerland) 2018 Oct 19;23(10)
Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection.
Tiwari PM, Vanover D, Lindsay KE, Bawage SS, Kirschman JL, Bhosle S, Lifland AW, Zurla C, Santangelo PJ
Nature communications 2018 Oct 1;9(1):3999
Nature communications 2018 Oct 1;9(1):3999
Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy.
Takaichi Y, Ano Y, Chambers JK, Uchida K, Takashima A, Nakayama H
Journal of neuropathology and experimental neurology 2018 Oct 1;77(10):920-928
Journal of neuropathology and experimental neurology 2018 Oct 1;77(10):920-928
Androgens modulate chronic intermittent hypoxia effects on brain and behavior.
Snyder B, Duong P, Trieu J, Cunningham RL
Hormones and behavior 2018 Nov;106:62-73
Hormones and behavior 2018 Nov;106:62-73
MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.
Lee CH, Holder M, Grau D, Saldaña-Meyer R, Yu JR, Ganai RA, Zhang J, Wang M, LeRoy G, Dobenecker MW, Reinberg D, Armache KJ
Molecular cell 2018 May 3;70(3):435-448.e5
Molecular cell 2018 May 3;70(3):435-448.e5
Transient stretch induces cytoskeletal fluidization through the severing action of cofilin.
Lan B, Krishnan R, Park CY, Watanabe RA, Panganiban R, Butler JP, Lu Q, Cole WC, Fredberg JJ
American journal of physiology. Lung cellular and molecular physiology 2018 May 1;314(5):L799-L807
American journal of physiology. Lung cellular and molecular physiology 2018 May 1;314(5):L799-L807
The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome.
Hayashi K, Taura M, Iwasaki A
Science signaling 2018 May 1;11(528)
Science signaling 2018 May 1;11(528)
Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice.
Li F, Yang J, Villar VAM, Asico LD, Ma X, Armando I, Sanada H, Yoneda M, Felder RA, Jose PA, Wang X
Diabetologia 2018 Mar;61(3):727-737
Diabetologia 2018 Mar;61(3):727-737
IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma.
Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T
Oncotarget 2018 Mar 6;9(18):14428-14443
Oncotarget 2018 Mar 6;9(18):14428-14443
Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets.
Macdougall CE, Wood EG, Loschko J, Scagliotti V, Cassidy FC, Robinson ME, Feldhahn N, Castellano L, Voisin MB, Marelli-Berg F, Gaston-Massuet C, Charalambous M, Longhi MP
Cell metabolism 2018 Mar 6;27(3):588-601.e4
Cell metabolism 2018 Mar 6;27(3):588-601.e4
Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence.
Mrazkova B, Dzijak R, Imrichova T, Kyjacova L, Barath P, Dzubak P, Holub D, Hajduch M, Nahacka Z, Andera L, Holicek P, Vasicova P, Sapega O, Bartek J, Hodny Z
Aging 2018 Mar 28;10(3):434-462
Aging 2018 Mar 28;10(3):434-462
Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.
Daniels LJ, Wallace RS, Nicholson OM, Wilson GA, McDonald FJ, Jones PP, Baldi JC, Lamberts RR, Erickson JR
Cardiovascular diabetology 2018 Jun 14;17(1):89
Cardiovascular diabetology 2018 Jun 14;17(1):89
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.
Snuderl M, Kannan K, Pfaff E, Wang S, Stafford JM, Serrano J, Heguy A, Ray K, Faustin A, Aminova O, Dolgalev I, Stapleton SL, Zagzag D, Chiriboga L, Gardner SL, Wisoff JH, Golfinos JG, Capper D, Hovestadt V, Rosenblum MK, Placantonakis DG, LeBoeuf SE, Papagiannakopoulos TY, Chavez L, Ahsan S, Eberhart CG, Pfister SM, Jones DTW, Karajannis MA
Nature communications 2018 Jul 20;9(1):2868
Nature communications 2018 Jul 20;9(1):2868
A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.
Bouhy D, Juneja M, Katona I, Holmgren A, Asselbergh B, De Winter V, Hochepied T, Goossens S, Haigh JJ, Libert C, Ceuterick-de Groote C, Irobi J, Weis J, Timmerman V
Acta neuropathologica 2018 Jan;135(1):131-148
Acta neuropathologica 2018 Jan;135(1):131-148
Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P2 during receptor-mediated endocytosis in yeast.
Yamamoto W, Wada S, Nagano M, Aoshima K, Siekhaus DE, Toshima JY, Toshima J
Journal of cell science 2018 Jan 4;131(1)
Journal of cell science 2018 Jan 4;131(1)
Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma.
Schultz CR, Geerts D, Mooney M, El-Khawaja R, Koster J, Bachmann AS
The Biochemical journal 2018 Jan 31;475(2):531-545
The Biochemical journal 2018 Jan 31;475(2):531-545
Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition.
Nguyen G, Park SY, Le CT, Park WS, Choi DH, Cho EH
Biochemical and biophysical research communications 2018 Jan 22;495(4):2649-2656
Biochemical and biophysical research communications 2018 Jan 22;495(4):2649-2656
MicroRNA-324-5p regulates stemness, pathogenesis and sensitivity to bortezomib in multiple myeloma cells by targeting hedgehog signaling.
Tang B, Xu A, Xu J, Huang H, Chen L, Su Y, Zhang L, Li J, Fan F, Deng J, Tang L, Sun C, Hu Y
International journal of cancer 2018 Jan 1;142(1):109-120
International journal of cancer 2018 Jan 1;142(1):109-120
Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein Is Crucial for Production of Infectious Virus Particles.
Su WC, Yu WY, Huang SH, Lai MMC
Journal of virology 2018 Feb 15;92(4)
Journal of virology 2018 Feb 15;92(4)
Bortezomib improves adoptive carbonic anhydrase IX‑specific chimeric antigen receptor‑modified NK92 cell therapy in mouse models of human renal cell carcinoma.
Zhang Q, Xu J, Ding J, Liu H, Li H, Li H, Lu M, Miao Y, Wang Z, Fu Q, Zheng J
Oncology reports 2018 Dec;40(6):3714-3724
Oncology reports 2018 Dec;40(6):3714-3724
Deletion of the Mitochondrial Complex-IV Cofactor Heme A:Farnesyltransferase Causes Focal Segmental Glomerulosclerosis and Interferon Response.
Baek JH, Gomez IG, Wada Y, Roach A, Mahad D, Duffield JS
The American journal of pathology 2018 Dec;188(12):2745-2762
The American journal of pathology 2018 Dec;188(12):2745-2762
Mechanisms of Matrix-Induced Chemoresistance of Breast Cancer Cells-Deciphering Novel Potential Targets for a Cell Sensitization.
Jakubzig B, Baltes F, Henze S, Schlesinger M, Bendas G
Cancers 2018 Dec 6;10(12)
Cancers 2018 Dec 6;10(12)
BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling.
Chung YH, Huang YH, Chu TH, Chen CL, Lin PR, Huang SC, Wu DC, Huang CC, Hu TH, Kao YH, Tai MH
Laboratory investigation; a journal of technical methods and pathology 2018 Aug;98(8):999-1013
Laboratory investigation; a journal of technical methods and pathology 2018 Aug;98(8):999-1013
PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease.
Juneja M, Azmi A, Baets J, Roos A, Jennings MJ, Saveri P, Pisciotta C, Bernard-Marissal N, Schneider BL, Verfaillie C, Chrast R, Seeman P, Hahn AF, de Jonghe P, Maudsley S, Horvath R, Pareyson D, Timmerman V
Journal of neurology, neurosurgery, and psychiatry 2018 Aug;89(8):870-878
Journal of neurology, neurosurgery, and psychiatry 2018 Aug;89(8):870-878
Somatic mutations activating Wiskott-Aldrich syndrome protein concomitant with RAS pathway mutations in juvenile myelomonocytic leukemia patients.
Coppe A, Nogara L, Pizzuto MS, Cani A, Cesaro S, Masetti R, Locatelli F, Te Kronnie G, Basso G, Bortoluzzi S, Bresolin S
Human mutation 2018 Apr;39(4):579-587
Human mutation 2018 Apr;39(4):579-587
9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1, 2-c]quinolin-11-one (BPIQ), A Quinoline Derivative Inhibits Human Hepatocellular Carcinoma Cells by Inducing ER Stress and Apoptosis.
Chang WT, Fong Y, Chuang SC, Chou CK, Chou HL, Yang CF, Tseng CH, Chen YL, Chiu CC
Anti-cancer agents in medicinal chemistry 2017;17(5):692-700
Anti-cancer agents in medicinal chemistry 2017;17(5):692-700
Using Histone Deacetylase Inhibitors to Analyze the Relevance of HDACs for Translation.
Hutt DM, Roth DM, Marchal C, Bouchecareilh M
Methods in molecular biology (Clifton, N.J.) 2017;1510:77-91
Methods in molecular biology (Clifton, N.J.) 2017;1510:77-91
ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency.
Joly P, Vignaud H, Di Martino J, Ruiz M, Garin R, Restier L, Belmalih A, Marchal C, Cullin C, Arveiler B, Fergelot P, Gitler AD, Lachaux A, Couthouis J, Bouchecareilh M
PloS one 2017;12(6):e0179369
PloS one 2017;12(6):e0179369
PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.
Respondek D, Voss M, Kühlewindt I, Klingel K, Krüger E, Beling A
PloS one 2017;12(3):e0173259
PloS one 2017;12(3):e0173259
FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.
Park JW, Lee JK, Witte ON, Huang J
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017 Sep;30(9):1262-1272
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017 Sep;30(9):1262-1272
Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV Receptor.
Pillay S, Zou W, Cheng F, Puschnik AS, Meyer NL, Ganaie SS, Deng X, Wosen JE, Davulcu O, Yan Z, Engelhardt JF, Brown KE, Chapman MS, Qiu J, Carette JE
Journal of virology 2017 Sep 15;91(18)
Journal of virology 2017 Sep 15;91(18)
MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation.
Zeng L, Chen Y, Wang Y, Yu LR, Knox B, Chen J, Shi T, Chen S, Ren Z, Guo L, Wu Y, Liu D, Huang K, Tong W, Yu D, Ning B
Biochemical pharmacology 2017 Sep 15;140:139-149
Biochemical pharmacology 2017 Sep 15;140:139-149
Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
Gimpel P, Lee YL, Sobota RM, Calvi A, Koullourou V, Patel R, Mamchaoui K, Nédélec F, Shackleton S, Schmoranzer J, Burke B, Cadot B, Gomes ER
Current biology : CB 2017 Oct 9;27(19):2999-3009.e9
Current biology : CB 2017 Oct 9;27(19):2999-3009.e9
ER phospholipid composition modulates lipogenesis during feeding and in obesity.
Rong X, Wang B, Palladino EN, de Aguiar Vallim TQ, Ford DA, Tontonoz P
The Journal of clinical investigation 2017 Oct 2;127(10):3640-3651
The Journal of clinical investigation 2017 Oct 2;127(10):3640-3651
Denervation-related alterations and biological activity of miRNAs contained in exosomes released by skeletal muscle fibers.
De Gasperi R, Hamidi S, Harlow LM, Ksiezak-Reding H, Bauman WA, Cardozo CP
Scientific reports 2017 Oct 16;7(1):12888
Scientific reports 2017 Oct 16;7(1):12888
MicroRNA-212/ABCG2-axis contributes to development of imatinib-resistance in leukemic cells.
Kaehler M, Ruemenapp J, Gonnermann D, Nagel I, Bruhn O, Haenisch S, Ammerpohl O, Wesch D, Cascorbi I, Bruckmueller H
Oncotarget 2017 Nov 3;8(54):92018-92031
Oncotarget 2017 Nov 3;8(54):92018-92031
FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.
Thompson EL, Yeo JE, Lee EA, Kan Y, Raghunandan M, Wiek C, Hanenberg H, Schärer OD, Hendrickson EA, Sobeck A
Nucleic acids research 2017 Nov 16;45(20):11837-11857
Nucleic acids research 2017 Nov 16;45(20):11837-11857
The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons.
Larhammar M, Huntwork-Rodriguez S, Rudhard Y, Sengupta-Ghosh A, Lewcock JW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Nov 15;37(46):11074-11084
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Nov 15;37(46):11074-11084
Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation.
Brifault C, Gilder AS, Laudati E, Banki M, Gonias SL
The Journal of biological chemistry 2017 Nov 10;292(45):18699-18712
The Journal of biological chemistry 2017 Nov 10;292(45):18699-18712
Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.
Chen Y, Liu W, Wang Y, Zhang L, Wei J, Zhang X, He F, Zhang L
Cellular signalling 2017 May;33:107-121
Cellular signalling 2017 May;33:107-121
Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure.
Fujiki K, Inamura H, Miyayama T, Matsuoka M
The Journal of biological chemistry 2017 May 12;292(19):7942-7953
The Journal of biological chemistry 2017 May 12;292(19):7942-7953
Obesity induces pro-inflammatory B cells and impairs B cell function in old mice.
Frasca D, Diaz A, Romero M, Vazquez T, Blomberg BB
Mechanisms of ageing and development 2017 Mar;162:91-99
Mechanisms of ageing and development 2017 Mar;162:91-99
TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.
Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ
Molecular oncology 2017 Mar;11(3):280-294
Molecular oncology 2017 Mar;11(3):280-294
The putative involvement of actin-binding proteins and cytoskeleton proteins in pathological mechanisms of ketamine cystitis-Revealed by a prospective pilot study using proteomic approaches.
Yang HH, Zhai WJ, Kuo HC
Proteomics. Clinical applications 2017 Mar;11(3-4)
Proteomics. Clinical applications 2017 Mar;11(3-4)
Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.
Bartova M, Hlavaty J, Tan Y, Singer C, Pohlodek K, Luha J, Walter I
Clinical & experimental metastasis 2017 Jun;34(5):333-344
Clinical & experimental metastasis 2017 Jun;34(5):333-344
Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice.
Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A
British journal of pharmacology 2017 Jun;174(12):1620-1632
British journal of pharmacology 2017 Jun;174(12):1620-1632
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
Zhang J, Johnson JL, He J, Napolitano G, Ramadass M, Rocca C, Kiosses WB, Bucci C, Xin Q, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD
The Journal of biological chemistry 2017 Jun 23;292(25):10328-10346
The Journal of biological chemistry 2017 Jun 23;292(25):10328-10346
Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease.
Fang F, Yang W, Florio JB, Rockenstein E, Spencer B, Orain XM, Dong SX, Li H, Chen X, Sung K, Rissman RA, Masliah E, Ding J, Wu C
Scientific reports 2017 Jun 20;7(1):3868
Scientific reports 2017 Jun 20;7(1):3868
Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13.
Scherer SL, Cain MD, Kanai SM, Kaltenbronn KM, Blumer KJ
The Journal of biological chemistry 2017 Jun 16;292(24):9906-9918
The Journal of biological chemistry 2017 Jun 16;292(24):9906-9918
DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cells.
Lee YH, Yang HW, Yang LC, Lu MY, Tsai LL, Yang SF, Huang YF, Chou MY, Yu CC, Hu FW
Oncology letters 2017 Jul;14(1):171-179
Oncology letters 2017 Jul;14(1):171-179
Presence of Androgen Receptor Variant in Neuronal Lipid Rafts.
Garza-Contreras J, Duong P, Snyder BD, Schreihofer DA, Cunningham RL
eNeuro 2017 Jul-Aug;4(4)
eNeuro 2017 Jul-Aug;4(4)
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Xiao X, Yang H, Arutiunian V, Fang Y, Besse G, Morimoto C, Zirkle B, Chen XS
Nucleic acids research 2017 Jul 7;45(12):7494-7506
Nucleic acids research 2017 Jul 7;45(12):7494-7506
Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway.
Lee KH, Chen CL, Lee YC, Kao TJ, Chen KY, Fang CY, Chang WC, Chiang YH, Huang CC
Scientific reports 2017 Jul 6;7(1):4787
Scientific reports 2017 Jul 6;7(1):4787
Generation of ribosome imprinted polymers for sensitive detection of translational responses.
King HA, El-Sharif HF, Matia-González AM, Iadevaia V, Fowotade A, Reddy SM, Gerber AP
Scientific reports 2017 Jul 26;7(1):6542
Scientific reports 2017 Jul 26;7(1):6542
The drebrin/EB3 pathway drives invasive activity in prostate cancer.
Dart AE, Worth DC, Muir G, Chandra A, Morris JD, McKee C, Verrill C, Bryant RJ, Gordon-Weeks PR
Oncogene 2017 Jul 20;36(29):4111-4123
Oncogene 2017 Jul 20;36(29):4111-4123
Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin.
Hammerling BC, Shires SE, Leon LJ, Cortez MQ, Gustafsson ÅB
Small GTPases 2017 Jul 11;:1-8
Small GTPases 2017 Jul 11;:1-8
Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure.
Guichard JL, Rogowski M, Agnetti G, Fu L, Powell P, Wei CC, Collawn J, Dell'Italia LJ
American journal of physiology. Heart and circulatory physiology 2017 Jul 1;313(1):H32-H45
American journal of physiology. Heart and circulatory physiology 2017 Jul 1;313(1):H32-H45
Excavatolide B Attenuates Rheumatoid Arthritis through the Inhibition of Osteoclastogenesis.
Lin YY, Jean YH, Lee HP, Lin SC, Pan CY, Chen WF, Wu SF, Su JH, Tsui KH, Sheu JH, Sung PJ, Wen ZH
Marine drugs 2017 Jan 6;15(1)
Marine drugs 2017 Jan 6;15(1)
A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.
Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn GW II, Sadoshima J, Ellisman MH, Gustafsson ÅB
Nature communications 2017 Jan 30;8:14050
Nature communications 2017 Jan 30;8:14050
Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma.
Baba Y, Maeda T, Suzuki A, Takada S, Fujii M, Kato Y
International journal of molecular sciences 2017 Jan 26;18(2)
International journal of molecular sciences 2017 Jan 26;18(2)
Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation.
Yang PY, Hsieh PL, Wang TH, Yu CC, Lu MY, Liao YW, Lee TH, Peng CY
Oncotarget 2017 Jan 17;8(3):4196-4207
Oncotarget 2017 Jan 17;8(3):4196-4207
Platelet activating factor-induced expression of p21 is correlated with histone acetylation.
Damiani E, Puebla-Osorio N, Lege BM, Liu J, Neelapu SS, Ullrich SE
Scientific reports 2017 Feb 3;7:41959
Scientific reports 2017 Feb 3;7:41959
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.
Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM
Cell 2017 Feb 23;168(5):890-903.e15
Cell 2017 Feb 23;168(5):890-903.e15
Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.
Delaney JR, Patel CB, Willis KM, Haghighiabyaneh M, Axelrod J, Tancioni I, Lu D, Bapat J, Young S, Cadassou O, Bartakova A, Sheth P, Haft C, Hui S, Saenz C, Schlaepfer DD, Harismendy O, Stupack DG
Nature communications 2017 Feb 15;8:14423
Nature communications 2017 Feb 15;8:14423
Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells.
Bressan RB, Dewari PS, Kalantzaki M, Gangoso E, Matjusaitis M, Garcia-Diaz C, Blin C, Grant V, Bulstrode H, Gogolok S, Skarnes WC, Pollard SM
Development (Cambridge, England) 2017 Feb 15;144(4):635-648
Development (Cambridge, England) 2017 Feb 15;144(4):635-648
Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation.
Shentu TP, Huang TS, Cernelc-Kohan M, Chan J, Wong SS, Espinoza CR, Tan C, Gramaglia I, van der Heyde H, Chien S, Hagood JS
Scientific reports 2017 Dec 22;7(1):18052
Scientific reports 2017 Dec 22;7(1):18052
VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
Jessen TN, Jessen JR
Experimental cell research 2017 Dec 15;361(2):265-276
Experimental cell research 2017 Dec 15;361(2):265-276
Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation.
Newman EA, Chukkapalli S, Bashllari D, Thomas TT, Van Noord RA, Lawlor ER, Hoenerhoff MJ, Opipari AW, Opipari VP
Cell death & disease 2017 Dec 13;8(12):3208
Cell death & disease 2017 Dec 13;8(12):3208
Dysregulation of the MEK/ERK/MNK1 signalling cascade by middle T antigen of the trichoydsplasia spinulosa polyomavirus.
Wu JH, Narayanan D, Simonette RA, Rady PL, Tyring SK
Journal of the European Academy of Dermatology and Venereology : JEADV 2017 Aug;31(8):1338-1341
Journal of the European Academy of Dermatology and Venereology : JEADV 2017 Aug;31(8):1338-1341
Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.
Wang VY, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, Ghosh G
Molecular cell 2017 Aug 3;67(3):484-497.e5
Molecular cell 2017 Aug 3;67(3):484-497.e5
Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals.
Preußner M, Goldammer G, Neumann A, Haltenhof T, Rautenstrauch P, Müller-McNicoll M, Heyd F
Molecular cell 2017 Aug 3;67(3):433-446.e4
Molecular cell 2017 Aug 3;67(3):433-446.e4
MiR-30a-5p Inhibits Epithelial-to-Mesenchymal Transition and Upregulates Expression of Tight Junction Protein Claudin-5 in Human Upper Tract Urothelial Carcinoma Cells.
Chung YH, Li SC, Kao YH, Luo HL, Cheng YT, Lin PR, Tai MH, Chiang PH
International journal of molecular sciences 2017 Aug 22;18(8)
International journal of molecular sciences 2017 Aug 22;18(8)
Molecular mechanisms supporting a pathogenic role for human polyomavirus 6 small T antigen: Protein phosphatase 2A targeting and MAPK cascade activation.
Wu JH, Simonette RA, Nguyen HP, Rady PL, Tyring SK
Journal of medical virology 2017 Apr;89(4):742-747
Journal of medical virology 2017 Apr;89(4):742-747
Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.
Chroma K, Mistrik M, Moudry P, Gursky J, Liptay M, Strauss R, Skrott Z, Vrtel R, Bartkova J, Kramara J, Bartek J
Oncogene 2017 Apr 27;36(17):2405-2422
Oncogene 2017 Apr 27;36(17):2405-2422
Activation-Dependent TRAF3 Exon 8 Alternative Splicing Is Controlled by CELF2 and hnRNP C Binding to an Upstream Intronic Element.
Schultz AS, Preussner M, Bunse M, Karni R, Heyd F
Molecular and cellular biology 2017 Apr 1;37(7)
Molecular and cellular biology 2017 Apr 1;37(7)
A Subpopulation of the K562 Cells Are Killed by Curcumin Treatment after G2/M Arrest and Mitotic Catastrophe.
Martinez-Castillo M, Bonilla-Moreno R, Aleman-Lazarini L, Meraz-Rios MA, Orozco L, Cedillo-Barron L, Cordova EJ, Villegas-Sepulveda N
PloS one 2016;11(11):e0165971
PloS one 2016;11(11):e0165971
c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells.
Hahm ER, Singh KB, Singh SV
Cell cycle (Georgetown, Tex.) 2016 Sep;15(17):2309-20
Cell cycle (Georgetown, Tex.) 2016 Sep;15(17):2309-20
Mycotoxin Patulin Suppresses Innate Immune Responses by Mitochondrial Dysfunction and p62/Sequestosome-1-dependent Mitophagy.
Tsai WT, Lo YC, Wu MS, Li CY, Kuo YP, Lai YH, Tsai Y, Chen KC, Chuang TH, Yao CH, Lee JC, Hsu LC, Hsu JT, Yu GY
The Journal of biological chemistry 2016 Sep 9;291(37):19299-311
The Journal of biological chemistry 2016 Sep 9;291(37):19299-311
Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells.
Jiang P, Zhang P, Mukthavaram R, Nomura N, Pingle SC, Teng D, Chien S, Guo F, Kesari S
Oncotarget 2016 Sep 6;7(36):57932-57942
Oncotarget 2016 Sep 6;7(36):57932-57942
Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON.
Kuga T, Kume H, Adachi J, Kawasaki N, Shimizu M, Hoshino I, Matsubara H, Saito Y, Nakayama Y, Tomonaga T
Scientific reports 2016 Sep 29;6:34472
Scientific reports 2016 Sep 29;6:34472
Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration.
Gan Z, Ding L, Burckhardt CJ, Lowery J, Zaritsky A, Sitterley K, Mota A, Costigliola N, Starker CG, Voytas DF, Tytell J, Goldman RD, Danuser G
Cell systems 2016 Sep 28;3(3):252-263.e8
Cell systems 2016 Sep 28;3(3):252-263.e8
Targeting the ERK pathway for the treatment of Cushing's disease.
Zhang D, Bergsneider M, Wang MB, Heaney AP
Oncotarget 2016 Oct 25;7(43):69149-69158
Oncotarget 2016 Oct 25;7(43):69149-69158
SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance.
Sheets JN, Iwanicki M, Liu JF, Howitt BE, Hirsch MS, Gubbels JA, Drapkin R, Egland KA
Oncogenesis 2016 Oct 24;5(10):e264
Oncogenesis 2016 Oct 24;5(10):e264
Expression of glycine receptors and gephyrin in rat medial vestibular nuclei and flocculi following unilateral labyrinthectomy.
Zhou W, Zhou LQ, Shi H, Leng YM, Liu B, Zhang SL, Kong WJ
International journal of molecular medicine 2016 Nov;38(5):1481-1489
International journal of molecular medicine 2016 Nov;38(5):1481-1489
Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines.
Edmonds S, Volpe A, Shmeeda H, Parente-Pereira AC, Radia R, Baguña-Torres J, Szanda I, Severin GW, Livieratos L, Blower PJ, Maher J, Fruhwirth GO, Gabizon A, T M de Rosales R
ACS nano 2016 Nov 22;10(11):10294-10307
ACS nano 2016 Nov 22;10(11):10294-10307
DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis.
Starokadomskyy P, Gemelli T, Rios JJ, Xing C, Wang RC, Li H, Pokatayev V, Dozmorov I, Khan S, Miyata N, Fraile G, Raj P, Xu Z, Xu Z, Ma L, Lin Z, Wang H, Yang Y, Ben-Amitai D, Orenstein N, Mussaffi H, Baselga E, Tadini G, Grunebaum E, Sarajlija A, Krzewski K, Wakeland EK, Yan N, de la Morena MT, Zinn AR, Burstein E
Nature immunology 2016 May;17(5):495-504
Nature immunology 2016 May;17(5):495-504
Chemotherapy-Induced Inflammatory Gene Signature and Protumorigenic Phenotype in Pancreatic CAFs via Stress-Associated MAPK.
Toste PA, Nguyen AH, Kadera BE, Duong M, Wu N, Gawlas I, Tran LM, Bikhchandani M, Li L, Patel SG, Dawson DW, Donahue TR
Molecular cancer research : MCR 2016 May;14(5):437-47
Molecular cancer research : MCR 2016 May;14(5):437-47
Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells.
Li YH, Choi DH, Lee EH, Seo SR, Lee S, Cho EH
The Journal of biological chemistry 2016 May 6;291(19):10277-92
The Journal of biological chemistry 2016 May 6;291(19):10277-92
FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes.
Kuga T, Sasaki M, Mikami T, Miake Y, Adachi J, Shimizu M, Saito Y, Koura M, Takeda Y, Matsuda J, Tomonaga T, Nakayama Y
Scientific reports 2016 May 25;6:26557
Scientific reports 2016 May 25;6:26557
CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.
Moreno-Lorenzana D, Avilés-Vazquez S, Sandoval Esquivel MA, Alvarado-Moreno A, Ortiz-Navarrete V, Torres-Martínez H, Ayala-Sánchez M, Mayani H, Chavez-Gonzalez A
Cell cycle (Georgetown, Tex.) 2016 May 2;15(9):1276-87
Cell cycle (Georgetown, Tex.) 2016 May 2;15(9):1276-87
Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.
Rowe ER, Mimmack ML, Barbosa AD, Haider A, Isaac I, Ouberai MM, Thiam AR, Patel S, Saudek V, Siniossoglou S, Savage DB
The Journal of biological chemistry 2016 Mar 25;291(13):6664-78
The Journal of biological chemistry 2016 Mar 25;291(13):6664-78
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM
Nature chemical biology 2016 Jun;12(6):452-8
Nature chemical biology 2016 Jun;12(6):452-8
KLF4 deletion alters gastric cell lineage and induces MUC2 expression.
Yu T, Chen X, Lin T, Liu J, Li M, Zhang W, Xu X, Zhao W, Liu M, Napier DL, Wang C, Evers BM, Liu C
Cell death & disease 2016 Jun 9;7(6):e2255
Cell death & disease 2016 Jun 9;7(6):e2255
Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.
Ahmad F, Chung YW, Tang Y, Hockman SC, Liu S, Khan Y, Huo K, Billings E, Amar MJ, Remaley AT, Manganiello VC
Scientific reports 2016 Jun 20;6:28056
Scientific reports 2016 Jun 20;6:28056
Arm Selection Preference of MicroRNA-193a Varies in Breast Cancer.
Tsai KW, Leung CM, Lo YH, Chen TW, Chan WC, Yu SY, Tu YT, Lam HC, Li SC, Ger LP, Liu WS, Chang HT
Scientific reports 2016 Jun 16;6:28176
Scientific reports 2016 Jun 16;6:28176
Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure.
Paudyal A, Dewan S, Ikie C, Whalley BJ, de Tombe PP, Boateng SY
The Journal of physiology 2016 Jun 15;594(12):3287-305
The Journal of physiology 2016 Jun 15;594(12):3287-305
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.
Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martín-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C
Nature communications 2016 Jul 27;7:12313
Nature communications 2016 Jul 27;7:12313
An essential receptor for adeno-associated virus infection.
Pillay S, Meyer NL, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, Carette JE
Nature 2016 Feb 4;530(7588):108-12
Nature 2016 Feb 4;530(7588):108-12
Sec16 alternative splicing dynamically controls COPII transport efficiency.
Wilhelmi I, Kanski R, Neumann A, Herdt O, Hoff F, Jacob R, Preußner M, Heyd F
Nature communications 2016 Aug 5;7:12347
Nature communications 2016 Aug 5;7:12347
Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins.
Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J
The Journal of biological chemistry 2016 Aug 26;291(35):18453-64
The Journal of biological chemistry 2016 Aug 26;291(35):18453-64
Crystal structures of APOBEC3G N-domain alone and its complex with DNA.
Xiao X, Li SX, Yang H, Chen XS
Nature communications 2016 Aug 2;7:12193
Nature communications 2016 Aug 2;7:12193
Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion.
Mankouri J, Walter C, Stewart H, Bentham M, Park WS, Heo WD, Fukuda M, Griffin S, Harris M
Journal of virology 2016 Aug 15;90(16):7159-70
Journal of virology 2016 Aug 15;90(16):7159-70
Efficient Mitochondrial Genome Editing by CRISPR/Cas9.
Jo A, Ham S, Lee GH, Lee YI, Kim S, Lee YS, Shin JH, Lee Y
BioMed research international 2015;2015:305716
BioMed research international 2015;2015:305716
PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes.
Kubli DA, Cortez MQ, Moyzis AG, Najor RH, Lee Y, Gustafsson ÅB
PloS one 2015;10(6):e0130707
PloS one 2015;10(6):e0130707
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.
Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J
The Journal of cell biology 2015 Sep 28;210(7):1117-31
The Journal of cell biology 2015 Sep 28;210(7):1117-31
CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer.
Paret C, Simon P, Vormbrock K, Bender C, Kölsch A, Breitkreuz A, Yildiz Ö, Omokoko T, Hubich-Rau S, Hartmann C, Häcker S, Wagner M, Roldan DB, Selmi A, Türeci Ö, Sahin U
Oncotarget 2015 Sep 22;6(28):25356-67
Oncotarget 2015 Sep 22;6(28):25356-67
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Virts EL, Jankowska A, Mackay C, Glaas MF, Wiek C, Kelich SL, Lottmann N, Kennedy FM, Marchal C, Lehnert E, Scharf RE, Dufour C, Lanciotti M, Farruggia P, Santoro A, Savasan S, Scheckenbach K, Schipper J, Wagenmann M, Lewis T, Leffak M, Farlow JL, Foroud TM, Honisch E, Niederacher D, Chakraborty SC, Vance GH, Pruss D, Timms KM, Lanchbury JS, Alpi AF, Hanenberg H
Human molecular genetics 2015 Sep 15;24(18):5093-108
Human molecular genetics 2015 Sep 15;24(18):5093-108
Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling.
Shi J, Liu Y, Xu X, Zhang W, Yu T, Jia J, Liu C
Molecular and cellular biology 2015 Oct;35(19):3301-11
Molecular and cellular biology 2015 Oct;35(19):3301-11
SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.
Zhang X, Coleman IM, Brown LG, True LD, Kollath L, Lucas JM, Lam HM, Dumpit R, Corey E, Chéry L, Lakely B, Higano CS, Montgomery B, Roudier M, Lange PH, Nelson PS, Vessella RL, Morrissey C
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Oct 15;21(20):4698-708
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Oct 15;21(20):4698-708
β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration.
Yu HW, Chen YQ, Huang CM, Liu CY, Chiou A, Wang YK, Tang MJ, Kuo JC
Journal of cellular and molecular medicine 2015 May;19(5):934-47
Journal of cellular and molecular medicine 2015 May;19(5):934-47
The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing.
Jacinto FV, Benner C, Hetzer MW
Genes & development 2015 Jun 15;29(12):1224-38
Genes & development 2015 Jun 15;29(12):1224-38
Roles of Phosphorylation of the Nucleocapsid Protein of Mumps Virus in Regulating Viral RNA Transcription and Replication.
Zengel J, Pickar A, Xu P, Lin A, He B
Journal of virology 2015 Jul;89(14):7338-47
Journal of virology 2015 Jul;89(14):7338-47
Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.
Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, Héon E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, Hollander AI, Cremers FP, Lopez I, Ren H, Moore AT, Webster AR, Michaelides M, Koenekoop RK, Zrenner E, Kaufman RJ, Tsang SH, Wissinger B, Lin JH
Nature genetics 2015 Jul;47(7):757-65
Nature genetics 2015 Jul;47(7):757-65
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.
Egerman MA, Cadena SM, Gilbert JA, Meyer A, Nelson HN, Swalley SE, Mallozzi C, Jacobi C, Jennings LL, Clay I, Laurent G, Ma S, Brachat S, Lach-Trifilieff E, Shavlakadze T, Trendelenburg AU, Brack AS, Glass DJ
Cell metabolism 2015 Jul 7;22(1):164-74
Cell metabolism 2015 Jul 7;22(1):164-74
BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9.
Chou CK, Wu CY, Chen JY, Ng MC, Wang HM, Chen JH, Yuan SS, Tsai EM, Chang JG, Chiu CC
International journal of molecular sciences 2015 Jul 3;16(7):15104-17
International journal of molecular sciences 2015 Jul 3;16(7):15104-17
The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis.
Huang TT, Ping YH, Wang AM, Ke CC, Fang WL, Huang KH, Lee HC, Chi CW, Yeh TS
Oncotarget 2015 Jul 20;6(20):18012-26
Oncotarget 2015 Jul 20;6(20):18012-26
Retbindin is an extracellular riboflavin-binding protein found at the photoreceptor/retinal pigment epithelium interface.
Kelley RA, Al-Ubaidi MR, Naash MI
The Journal of biological chemistry 2015 Feb 20;290(8):5041-52
The Journal of biological chemistry 2015 Feb 20;290(8):5041-52
Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.
Ma F, Li B, Liu SY, Iyer SS, Yu Y, Wu A, Cheng G
Journal of immunology (Baltimore, Md. : 1950) 2015 Feb 15;194(4):1545-54
Journal of immunology (Baltimore, Md. : 1950) 2015 Feb 15;194(4):1545-54
DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance.
Huber RM, Lucas JM, Gomez-Sarosi LA, Coleman I, Zhao S, Coleman R, Nelson PS
Oncotarget 2015 Feb 10;6(4):2134-47
Oncotarget 2015 Feb 10;6(4):2134-47
Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration.
Wu JC, Chen YC, Kuo CT, Wenshin Yu H, Chen YQ, Chiou A, Kuo JC
Scientific reports 2015 Dec 18;5:18476
Scientific reports 2015 Dec 18;5:18476
Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade.
Lin TB, Hsieh MC, Lai CY, Cheng JK, Chau YP, Ruan T, Chen GD, Peng HY
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Dec 16;35(50):16545-60
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Dec 16;35(50):16545-60
Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5.
Tian H, Lu JY, Shao C, Huffman KE, Carstens RM, Larsen JE, Girard L, Liu H, Rodriguez-Canales J, Frenkel EP, Wistuba II, Minna JD, Hofmann SL
Molecular cancer research : MCR 2015 Apr;13(4):784-94
Molecular cancer research : MCR 2015 Apr;13(4):784-94
The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage.
Fu H, Martin MM, Regairaz M, Huang L, You Y, Lin CM, Ryan M, Kim R, Shimura T, Pommier Y, Aladjem MI
Nature communications 2015 Apr 16;6:6746
Nature communications 2015 Apr 16;6:6746
The histone deacetylase inhibitor, Vorinostat, represses hypoxia inducible factor 1 alpha expression through translational inhibition.
Hutt DM, Roth DM, Vignaud H, Cullin C, Bouchecareilh M
PloS one 2014;9(8):e106224
PloS one 2014;9(8):e106224
Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.
Johnson MA, Vidoni S, Durigon R, Pearce SF, Rorbach J, He J, Brea-Calvo G, Minczuk M, Reyes A, Holt IJ, Spinazzola A
PloS one 2014;9(4):e93597
PloS one 2014;9(4):e93597
miR-7 and miR-153 protect neurons against MPP(+)-induced cell death via upregulation of mTOR pathway.
Fragkouli A, Doxakis E
Frontiers in cellular neuroscience 2014;8:182
Frontiers in cellular neuroscience 2014;8:182
Andrographolide induces apoptosis of C6 glioma cells via the ERK-p53-caspase 7-PARP pathway.
Yang SH, Wang SM, Syu JP, Chen Y, Wang SD, Peng YS, Kuo MF, Kung HN
BioMed research international 2014;2014:312847
BioMed research international 2014;2014:312847
The effect of sesamin on airway fibrosis in vitro and in vivo.
Lin CH, Shen ML, Kao ST, Wu DC
International immunopharmacology 2014 Sep;22(1):141-50
International immunopharmacology 2014 Sep;22(1):141-50
Tumor necrosis factor-alpha mediates activation of NF-κB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways.
Dvoriantchikova G, Ivanov D
The European journal of neuroscience 2014 Oct;40(8):3171-8
The European journal of neuroscience 2014 Oct;40(8):3171-8
Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation.
Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 Oct;34(10):1637-45
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 Oct;34(10):1637-45
Lentiviral delivery of PPARγ shRNA alters the balance of osteogenesis and adipogenesis, improving bone microarchitecture.
James AW, Shen J, Khadarian K, Pang S, Chung G, Goyal R, Asatrian G, Velasco O, Kim J, Zhang X, Ting K, Soo C
Tissue engineering. Part A 2014 Oct;20(19-20):2699-710
Tissue engineering. Part A 2014 Oct;20(19-20):2699-710
Single-cell Western blotting after whole-cell imaging to assess cancer chemotherapeutic response.
Kang CC, Lin JM, Xu Z, Kumar S, Herr AE
Analytical chemistry 2014 Oct 21;86(20):10429-36
Analytical chemistry 2014 Oct 21;86(20):10429-36
GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment.
Huang IH, Hsiao CT, Wu JC, Shen RF, Liu CY, Wang YK, Chen YC, Huang CM, del Álamo JC, Chang ZF, Tang MJ, Khoo KH, Kuo JC
Journal of cell science 2014 Oct 1;127(Pt 19):4186-200
Journal of cell science 2014 Oct 1;127(Pt 19):4186-200
FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks.
Chaudhury I, Stroik DR, Sobeck A
Molecular and cellular biology 2014 Nov;34(21):3939-54
Molecular and cellular biology 2014 Nov;34(21):3939-54
Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon.
Ma F, Liu SY, Razani B, Arora N, Li B, Kagechika H, Tontonoz P, Núñez V, Ricote M, Cheng G
Nature communications 2014 Nov 24;5:5494
Nature communications 2014 Nov 24;5:5494
Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer.
Hall WA, Petrova AV, Colbert LE, Hardy CW, Fisher SB, Saka B, Shelton JW, Warren MD, Pantazides BG, Gandhi K, Kowalski J, Kooby DA, El-Rayes BF, Staley CA 3rd, Volkan Adsay N, Curran WJ, Landry JC, Maithel SK, Yu DS
Oncogene 2014 Nov 20;33(47):5450-6
Oncogene 2014 Nov 20;33(47):5450-6
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.
Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM
Cancer discovery 2014 May;4(5):554-63
Cancer discovery 2014 May;4(5):554-63
CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer.
Colbert LE, Petrova AV, Fisher SB, Pantazides BG, Madden MZ, Hardy CW, Warren MD, Pan Y, Nagaraju GP, Liu EA, Saka B, Hall WA, Shelton JW, Gandhi K, Pauly R, Kowalski J, Kooby DA, El-Rayes BF, Staley CA 3rd, Adsay NV, Curran WJ Jr, Landry JC, Maithel SK, Yu DS
Cancer research 2014 May 15;74(10):2677-87
Cancer research 2014 May 15;74(10):2677-87
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
Kohsaka S, Shukla N, Ameur N, Ito T, Ng CK, Wang L, Lim D, Marchetti A, Viale A, Pirun M, Socci ND, Qin LX, Sciot R, Bridge J, Singer S, Meyers P, Wexler LH, Barr FG, Dogan S, Fletcher JA, Reis-Filho JS, Ladanyi M
Nature genetics 2014 Jun;46(6):595-600
Nature genetics 2014 Jun;46(6):595-600
CtIP mediates replication fork recovery in a FANCD2-regulated manner.
Yeo JE, Lee EH, Hendrickson EA, Sobeck A
Human molecular genetics 2014 Jul 15;23(14):3695-705
Human molecular genetics 2014 Jul 15;23(14):3695-705
Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy.
Liu SH, Lin CH, Liang FP, Chen PF, Kuo CD, Alam MM, Maiti B, Hung SK, Chi CW, Sun CM, Fu SL
Biochemical pharmacology 2014 Jan 15;87(2):229-42
Biochemical pharmacology 2014 Jan 15;87(2):229-42
Nrf2 protects against TWEAK-mediated skeletal muscle wasting.
Al-Sawaf O, Fragoulis A, Rosen C, Kan YW, Sönmez TT, Pufe T, Wruck CJ
Scientific reports 2014 Jan 10;4:3625
Scientific reports 2014 Jan 10;4:3625
Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake.
Yang M, Liu W, Pellicane C, Sahyoun C, Joseph BK, Gallo-Ebert C, Donigan M, Pandya D, Giordano C, Bata A, Nickels JT Jr
Journal of lipid research 2014 Feb;55(2):226-38
Journal of lipid research 2014 Feb;55(2):226-38
Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse.
Corradini E, Vallur R, Raaijmakers LM, Feil S, Feil R, Heck AJ, Scholten A
Molecular & cellular proteomics : MCP 2014 Aug;13(8):2004-16
Molecular & cellular proteomics : MCP 2014 Aug;13(8):2004-16
Decorin differentially modulates the activity of insulin receptor isoform A ligands.
Morcavallo A, Buraschi S, Xu SQ, Belfiore A, Schaefer L, Iozzo RV, Morrione A
Matrix biology : journal of the International Society for Matrix Biology 2014 Apr;35:82-90
Matrix biology : journal of the International Society for Matrix Biology 2014 Apr;35:82-90
Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death.
Ruisu K, Kask K, Meier R, Saare M, Raid R, Veraksitš A, Karis A, Tõnissoo T, Pooga M
PloS one 2013;8(8):e74031
PloS one 2013;8(8):e74031
Zfp423 binds autoregulatory sites in p19 cell culture model.
Cho YW, Hong CJ, Hou A, Gent PM, Zhang K, Won KJ, Hamilton BA
PloS one 2013;8(6):e66514
PloS one 2013;8(6):e66514
Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.
Lam T, Thomas LM, White CA, Li G, Pone EJ, Xu Z, Casali P
PloS one 2013;8(11):e80414
PloS one 2013;8(11):e80414
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
Lin W, Sampathi S, Dai H, Liu C, Zhou M, Hu J, Huang Q, Campbell J, Shin-Ya K, Zheng L, Chai W, Shen B
The EMBO journal 2013 May 15;32(10):1425-39
The EMBO journal 2013 May 15;32(10):1425-39
FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Chaudhury I, Sareen A, Raghunandan M, Sobeck A
Nucleic acids research 2013 Jul;41(13):6444-59
Nucleic acids research 2013 Jul;41(13):6444-59
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ
Cell metabolism 2013 Jan 8;17(1):49-60
Cell metabolism 2013 Jan 8;17(1):49-60
Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
Yang Y, Durando M, Smith-Roe SL, Sproul C, Greenwalt AM, Kaufmann W, Oh S, Hendrickson EA, Vaziri C
Nucleic acids research 2013 Feb 1;41(4):2296-312
Nucleic acids research 2013 Feb 1;41(4):2296-312
SIL1 mutations and clinical spectrum in patients with Marinesco-Sjogren syndrome.
Krieger M, Roos A, Stendel C, Claeys KG, Sonmez FM, Baudis M, Bauer P, Bornemann A, de Goede C, Dufke A, Finkel RS, Goebel HH, Häussler M, Kingston H, Kirschner J, Medne L, Muschke P, Rivier F, Rudnik-Schöneborn S, Spengler S, Inzana F, Stanzial F, Benedicenti F, Synofzik M, Lia Taratuto A, Pirra L, Tay SK, Topaloglu H, Uyanik G, Wand D, Williams D, Zerres K, Weis J, Senderek J
Brain : a journal of neurology 2013 Dec;136(Pt 12):3634-44
Brain : a journal of neurology 2013 Dec;136(Pt 12):3634-44
Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA.
Angulo-Rojo C, Manning-Cela R, Aguirre A, Ortega A, López-Bayghen E
ASN neuro 2013 Dec 23;5(5):e00130
ASN neuro 2013 Dec 23;5(5):e00130
Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin.
Son J, Shen SS, Margueron R, Reinberg D
Genes & development 2013 Dec 15;27(24):2663-77
Genes & development 2013 Dec 15;27(24):2663-77
Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Chang YC, Yu YH, Shew JY, Lee WJ, Hwang JJ, Chen YH, Chen YR, Wei PC, Chuang LM, Lee WH
EMBO molecular medicine 2013 Aug;5(8):1165-79
EMBO molecular medicine 2013 Aug;5(8):1165-79
Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling.
Zhang K, Fishel Ben Kenan R, Osakada Y, Xu W, Sinit RS, Chen L, Zhao X, Chen JY, Cui B, Wu C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 24;33(17):7451-62
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 24;33(17):7451-62
Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy.
Sun Y, Vashisht AA, Tchieu J, Wohlschlegel JA, Dreier L
The Journal of biological chemistry 2012 Nov 23;287(48):40652-60
The Journal of biological chemistry 2012 Nov 23;287(48):40652-60
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
Lim ST, Miller NL, Chen XL, Tancioni I, Walsh CT, Lawson C, Uryu S, Weis SM, Cheresh DA, Schlaepfer DD
The Journal of cell biology 2012 Jun 25;197(7):907-19
The Journal of cell biology 2012 Jun 25;197(7):907-19
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Supportive validation
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- Sample (30 ?g of whole cell lysate) A: Drosophila 10% SDS PAGE GTX627408 diluted at 1:5000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- GAPDH antibody [GT239] detects GAPDH protein by western blot analysis.A. 30 ?g whole zebrafish lysate/extract10% SDS-PAGEGAPDH antibody [GT239] (GTX627408) dilution: 1:500 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- GAPDH antibody [GT239] detects GAPDH protein by western blot analysis.A. 20 ?g 293T whole cell lysate/extractB. 10 ?g 293T whole cell lysate/extractC. 5 ?g 293T whole cell lysate/extractD. 1 ?g 293T whole cell lysate/extract10% SDS-PAGEGAPDH antibody [GT239] (GTX627408) dilution: 1:10000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- GAPDH antibody [GT239] detects GAPDH protein by western blot analysis.A. 30 ?g 293T whole cell lysate/extractB. 30 ?g NIH-3T3 whole cell lysate/extractC. 30 ?g mouse brain lysate/extractD. 30 ?g PC-12 whole cell lysate/extractE. 30 ?g rat brain lysate/extract10% SDS-PAGEGAPDH antibody [GT239] (GTX627408) dilution: 1:10000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- GAPDH antibody [GT239] detects GAPDH protein by western blot analysis.A. 30 ?g Jurkat whole cell lysate/extractB. 30 ?g Raji whole cell lysate/extractC. 30 ?g 293T whole cell lysate/extractD. 30 ?g A431 whole cell lysate/extractE. 30 ?g HeLa whole cell lysate/extractF. 30 ?g HepG2 whole cell lysate/extractG. 30 ?g H1299 whole cell lysate/extractH. 30 ?g HCT116 whole cell lysate/extractI. 30 ?g MCF-7 whole cell lysate/extractJ. 30 ?g NT2D1 whole cell lysate/extractK. 30 ?g PC-3 whole cell lysate/extractL. 30 ?g U87-MG whole cell lysate/extract10% SDS-PAGEGAPDH antibody [GT239] (GTX627408) dilution: 1:10000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- GAPDH antibody [GT239] detects GAPDH protein by western blot analysis.A. 30 ?g yeast whole cell lysate/extract10% SDS-PAGEGAPDH antibody [GT239] (GTX627408) dilution: 1:10000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- Main image
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- Whole cell extract (30 ?g) was separated by 10% SDS-PAGE, and the membrane was blotted with GAPDH antibody [GT239] (GTX627408) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
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- Various whole cell extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with (GTX627408) diluted at 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
Supportive validation
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- GAPDH antibody [GT239] detects GAPDH protein at cytoplasm by immunofluorescent analysis.Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 10 min.Green: GAPDH protein stained by GAPDH antibody [GT239] (GTX627408) diluted at 1:100.Blue: Hoechst 33342 staining.Scale bar = 10 £gm.
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- GAPDH antibody [GT239] detects GAPDH protein at cytoplasm by immunofluorescent analysis.Sample: HeLa cells were fixed in ice-cold MeOH for 5 min.Green: GAPDH stained by GAPDH antibody [GT239] (GTX627408) diluted at 1:500.Blue: Hoechst 33342 staining.
Supportive validation
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- GAPDH antibody [GT239] detects GAPDH protein at cytosol on U373 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded U373 xenograft. GAPDH antibody [GT239] (GTX627408) dilution: 1:200.
