Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS8262 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- FLCN polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human FLCN.
- Description
- Birt-Hogg-Dub¹È (BHD) syndrome is a rare autosomal dominant cancer syndrome characterized by kidney tumors, benign tumors of the hair follicle and spontaneous pneumothorax. BHD is also associated with neoplastic colonic polyps. The BHD gene maps to chromosome 17p11.2 and encodes the protein folliculin. Folliculin is widely expressed. Notably, folliculin is expressed in the kidney, lung and skin, where BHD tumors arise. Specifically, the (C)8 tract in exon 11 is a mutational hot spot in BHD. BHD appears to have reduced penetrance or late onset. In a study of the renal tumors in 30 BHD patients, preoperative computed tomography scans detect a mean of 5.3 tumors per patient with a range 1-28 tumors. Multiple and bilateral tumors appear at a mean of 50.7 years.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of FLCN polyclonal antibody