BS8262

antibody from Bioworld Technology, Inc
Targeting: FLCN BHD, DENND8B, MGC17998, MGC23445
Provider product page for BS8262
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8262 - Provider product page
Provider
Bioworld Technology, Inc
Product name
FLCN polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human FLCN.
Description
Birt-Hogg-Dub¹È (BHD) syndrome is a rare autosomal dominant cancer syndrome characterized by kidney tumors, benign tumors of the hair follicle and spontaneous pneumothorax. BHD is also associated with neoplastic colonic polyps. The BHD gene maps to chromosome 17p11.2 and encodes the protein folliculin. Folliculin is widely expressed. Notably, folliculin is expressed in the kidney, lung and skin, where BHD tumors arise. Specifically, the (C)8 tract in exon 11 is a mutational hot spot in BHD. BHD appears to have reduced penetrance or late onset. In a study of the renal tumors in 30 BHD patients, preoperative computed tomography scans detect a mean of 5.3 tumors per patient with a range 1-28 tumors. Multiple and bilateral tumors appear at a mean of 50.7 years.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
FLCN protein structure - BS8262 shown in red.