Antibody data

Product number
NBP2-48135 - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal HLA DRB1 Antibody
Antibody type
Monoclonal
Description
Protein A or G purified. This MAb reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. Its epitope is different from that of MAb L243. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
Reactivity
Human, Simian
Host
Mouse
Isotype
IgG
Vial size
7 ml
Storage
Store at 4C.
HLA-DRB1 protein structure - NBP2-48135 shown in red.