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- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Flow cytometry [1]
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- Product number
- 307611 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#307611, RRID:AB_314689
- Product name
- LEAF™ Purified anti-human HLA-DR [L243]
- Antibody type
- Monoclonal
- Antigen
- HLA-DR
- Description
- HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kD α (heavy) chain and a 27 kD β (light) chain. It is expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells.
- Reactivity
- Human, Canine, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 50 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
Submitted references CD4+ CD25+ Foxp3+ regulatory T cells, dendritic cells, and circulating cytokines in uncomplicated malaria: do different parasite species elicit similar host responses?
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production.
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses.
Gonçalves RM, Salmazi KC, Santos BA, Bastos MS, Rocha SC, Boscardin SB, Silber AM, Kallás EG, Ferreira MU, Scopel KK
Infection and immunity 2010 Nov;78(11):4763-72
Infection and immunity 2010 Nov;78(11):4763-72
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Charles N, Hardwick D, Daugas E, Illei GG, Rivera J
Nature medicine 2010 Jun;16(6):701-7
Nature medicine 2010 Jun;16(6):701-7
Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production.
Fujita H, Nograles KE, Kikuchi T, Gonzalez J, Carucci JA, Krueger JG
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 22;106(51):21795-800
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 22;106(51):21795-800
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses.
Zaba LC, Cardinale I, Gilleaudeau P, Sullivan-Whalen M, Suárez-Fariñas M, Fuentes-Duculan J, Novitskaya I, Khatcherian A, Bluth MJ, Lowes MA, Krueger JG
The Journal of experimental medicine 2007 Dec 24;204(13):3183-94
The Journal of experimental medicine 2007 Dec 24;204(13):3183-94
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with LEAF™ purified L243, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated
