Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- orb97033 - Provider product page
- Provider
- Biorbyt
- Product name
- CYP1A2 antibody
- Antibody type
- Polyclonal
- Description
- Rabbit Polyclonal to CYP1A2. CYP1A2(Cytochrome P450, Subfamily I, Polypeptide 2) is a member of the cytochrome P450 mixed-function oxidase system and is involved in the metabolism of xenobiotics in the body. CYP1A2 is a member of the cytochrome P450 superfamily of enzymes. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene. CYP1A2 localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The CYP1A2 gene encodes a P450 enzyme involved in O-deethylation of phenacetin. Ikeya et al. (1989) found that the human CYP1A2 gene spans almost 7.8 kb and contains 7 exons.The CYP1A2 gene is mapped on 15q24.1.CYP1A2 accounts for nearly 15% of the cytochrome P450 in the human liver. CYP1A2 displays higher activity in men than in women, and is inhibited by oral contraceptives. Inducers of CYP1A2 include cruciferous vegetables. Cigarette smoking has also been shown to increaseCYP1A2 activity. Expression of CYP1A2 appears to be induced by various dietary constituents.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 100 μg
- Concentration
- 0.1-0.5 μg/ml,0.5-1 μg/ml
- Storage
- Store at -20°C for one year.After reconstitution, at 4°C. for one month. It can also be aliquotted and stored frozen at -20°C. for a longer time.Avoid repeated freezing and thawing.
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Supportive validation
- Submitted by
- Biorbyt (provider)
- Main image
- Experimental details
- Western blot analysis of Lane 1: Rat Liver Tissue Lysate, Lane 2: Rat Liver Tissue Lysate, Lane 3: SMMC Cell Lysate, Lane 4: HEPA Cell Lysate using CYP1A2 antibody
Supportive validation
- Submitted by
- Biorbyt (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of formalin-fixed paraffin embedded Rat Liver Tissue using CYP1A2 antibody