Antibody data
- Antibody Data
- Antigen structure
- References [43]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11510-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11510-1-AP, RRID:AB_2217459
- Product name
- YME1L1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated YME1L1 antibody (Cat. #11510-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly.
Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells.
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion.
Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing.
Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice.
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.
NAD+ precursor increases aerobic performance in mice.
Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes.
A High-Density Human Mitochondrial Proximity Interaction Network.
Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space.
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.
Prohibitin levels regulate OMA1 activity and turnover in neurons.
p32/C1QBP regulates OMA1-dependent proteolytic processing of OPA1 to maintain mitochondrial connectivity related to mitochondrial dysfunction and apoptosis.
The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts.
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.
Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.
ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response.
Laminar shear stress promotes mitochondrial homeostasis in endothelial cells.
PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria.
m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics.
Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
Proteolytic control of the mitochondrial calcium uniporter complex.
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.
Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.
Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.
Loss of Yme1L perturbates mitochondrial dynamics.
Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.
SLP-2 is required for stress-induced mitochondrial hyperfusion.
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1.
Wang T, Liu H, Itoh K, Oh S, Zhao L, Murata D, Sesaki H, Hartung T, Na CH, Wang J
Cell metabolism 2021 Mar 2;33(3):531-546.e9
Cell metabolism 2021 Mar 2;33(3):531-546.e9
Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells.
Haschler TN, Horsley H, Balys M, Anderson G, Taanman JW, Unwin RJ, Norman JT
Scientific reports 2021 Jul 30;11(1):15510
Scientific reports 2021 Jul 30;11(1):15510
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.
Kakehashi A, Suzuki S, Shiota M, Raymo N, Gi M, Tachibana T, Stefanov V, Wanibuchi H
Cancers 2021 Jul 19;13(14)
Cancers 2021 Jul 19;13(14)
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827
EMBO reports 2021 Jan 7;22(1):e50827
Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion.
Wang R, Mishra P, Garbis SD, Moradian A, Sweredoski MJ, Chan DC
Molecular biology of the cell 2021 Jan 15;32(2):157-168
Molecular biology of the cell 2021 Jan 15;32(2):157-168
Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing.
Douida A, Batista F, Boto P, Regdon Z, Robaszkiewicz A, Tar K
International journal of molecular sciences 2021 Feb 5;22(4)
International journal of molecular sciences 2021 Feb 5;22(4)
Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice.
Braga RR, Crisol BM, Brícola RS, Sant'ana MR, Nakandakari SCBR, Costa SO, Prada PO, da Silva ASR, Moura LP, Pauli JR, Cintra DE, Ropelle ER
Scientific reports 2021 Feb 15;11(1):3813
Scientific reports 2021 Feb 15;11(1):3813
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.
Scott GK, Mahoney S, Scott M, Loureiro A, Lopez-Ramirez A, Tanner JJ, Ellerby LM, Benz CC
Amino acids 2021 Dec;53(12):1927-1939
Amino acids 2021 Dec;53(12):1927-1939
NAD+ precursor increases aerobic performance in mice.
Crisol BM, Veiga CB, Braga RR, Lenhare L, Baptista IL, Gaspar RC, Muñoz VR, Cordeiro AV, da Silva ASR, Cintra DE, Moura LP, Pauli JR, Ropelle ER
European journal of nutrition 2020 Sep;59(6):2427-2437
European journal of nutrition 2020 Sep;59(6):2427-2437
Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes.
Aishwarya R, Alam S, Abdullah CS, Morshed M, Nitu SS, Panchatcharam M, Miriyala S, Kevil CG, Bhuiyan MS
Redox biology 2020 Sep;36:101660
Redox biology 2020 Sep;36:101660
A High-Density Human Mitochondrial Proximity Interaction Network.
Antonicka H, Lin ZY, Janer A, Aaltonen MJ, Weraarpachai W, Gingras AC, Shoubridge EA
Cell metabolism 2020 Sep 1;32(3):479-497.e9
Cell metabolism 2020 Sep 1;32(3):479-497.e9
Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space.
Thevarajan I, Zolkiewski M, Zolkiewska A
The international journal of biochemistry & cell biology 2020 Oct;127:105841
The international journal of biochemistry & cell biology 2020 Oct;127:105841
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
Hu C, Shu L, Huang X, Yu J, Li L, Gong L, Yang M, Wu Z, Gao Z, Zhao Y, Chen L, Song Z
Cell death & disease 2020 Oct 31;11(10):940
Cell death & disease 2020 Oct 31;11(10):940
CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.
Liu T, Woo JA, Bukhari MZ, LePochat P, Chacko A, Selenica MB, Yan Y, Kotsiviras P, Buosi SC, Zhao X, Kang DE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8493-8509
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8493-8509
Prohibitin levels regulate OMA1 activity and turnover in neurons.
Anderson CJ, Kahl A, Fruitman H, Qian L, Zhou P, Manfredi G, Iadecola C
Cell death and differentiation 2020 Jun;27(6):1896-1906
Cell death and differentiation 2020 Jun;27(6):1896-1906
p32/C1QBP regulates OMA1-dependent proteolytic processing of OPA1 to maintain mitochondrial connectivity related to mitochondrial dysfunction and apoptosis.
Noh S, Phorl S, Naskar R, Oeum K, Seo Y, Kim E, Kweon HS, Lee JY
Scientific reports 2020 Jun 30;10(1):10618
Scientific reports 2020 Jun 30;10(1):10618
The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts.
Horibata Y, Mitsuhashi S, Shimizu H, Maejima S, Sakamoto H, Aoyama C, Ando H, Sugimoto H
Scientific reports 2020 Feb 18;10(1):2845
Scientific reports 2020 Feb 18;10(1):2845
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Aras S, Purandare N, Gladyck S, Somayajulu-Nitu M, Zhang K, Wallace DC, Grossman LI
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065
Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.
Mohanraj K, Wasilewski M, Benincá C, Cysewski D, Poznanski J, Sakowska P, Bugajska Z, Deckers M, Dennerlein S, Fernandez-Vizarra E, Rehling P, Dadlez M, Zeviani M, Chacinska A
EMBO molecular medicine 2019 May;11(5)
EMBO molecular medicine 2019 May;11(5)
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.
Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
Molecular cell 2019 Mar 7;73(5):1028-1043.e5
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X
Nature communications 2019 Mar 26;10(1):1371
Nature communications 2019 Mar 26;10(1):1371
Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.
Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T
EMBO molecular medicine 2019 Jan;11(1)
EMBO molecular medicine 2019 Jan;11(1)
Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.
Nakazawa H, Ikeda K, Shinozaki S, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Yorozu T, Inoue S, Kaneki M
FEBS open bio 2019 Feb;9(2):348-363
FEBS open bio 2019 Feb;9(2):348-363
ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P
The Journal of cell biology 2019 Feb 4;218(2):598-614
The Journal of cell biology 2019 Feb 4;218(2):598-614
LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response.
Zurita Rendón O, Shoubridge EA
Molecular and cellular biology 2018 Oct 15;38(20)
Molecular and cellular biology 2018 Oct 15;38(20)
Laminar shear stress promotes mitochondrial homeostasis in endothelial cells.
Wu LH, Chang HC, Ting PC, Wang DL
Journal of cellular physiology 2018 Jun;233(6):5058-5069
Journal of cellular physiology 2018 Jun;233(6):5058-5069
PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria.
Saita S, Tatsuta T, Lampe PA, König T, Ohba Y, Langer T
The EMBO journal 2018 Feb 15;37(4)
The EMBO journal 2018 Feb 15;37(4)
m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics.
Consolato F, Maltecca F, Tulli S, Sambri I, Casari G
Journal of cell science 2018 Apr 9;131(7)
Journal of cell science 2018 Apr 9;131(7)
Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.
Vukotic M, Nolte H, König T, Saita S, Ananjew M, Krüger M, Tatsuta T, Langer T
Molecular cell 2017 Aug 3;67(3):471-483.e7
Molecular cell 2017 Aug 3;67(3):471-483.e7
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T
Nature cell biology 2017 Apr;19(4):318-328
Nature cell biology 2017 Apr;19(4):318-328
Proteolytic control of the mitochondrial calcium uniporter complex.
Tsai CW, Wu Y, Pao PC, Phillips CB, Williams C, Miller C, Ranaghan M, Tsai MF
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4388-4393
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4388-4393
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92
Cell death and differentiation 2016 Mar;23(3):380-92
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.
Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T
EMBO reports 2016 Dec;17(12):1844-1856
EMBO reports 2016 Dec;17(12):1844-1856
Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress.
Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD
Journal of molecular and cellular cardiology 2016 Aug;97:1-14
Journal of molecular and cellular cardiology 2016 Aug;97:1-14
Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury.
Baburamani AA, Hurling C, Stolp H, Sobotka K, Gressens P, Hagberg H, Thornton C
International journal of molecular sciences 2015 Sep 17;16(9):22509-26
International journal of molecular sciences 2015 Sep 17;16(9):22509-26
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.
Richter U, Lahtinen T, Marttinen P, Suomi F, Battersby BJ
The Journal of cell biology 2015 Oct 26;211(2):373-89
The Journal of cell biology 2015 Oct 26;211(2):373-89
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.
Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, Langer T
Cell metabolism 2014 Jul 1;20(1):158-71
Cell metabolism 2014 Jul 1;20(1):158-71
Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.
Mishra P, Carelli V, Manfredi G, Chan DC
Cell metabolism 2014 Apr 1;19(4):630-41
Cell metabolism 2014 Apr 1;19(4):630-41
Loss of Yme1L perturbates mitochondrial dynamics.
Ruan Y, Li H, Zhang K, Jian F, Tang J, Song Z
Cell death & disease 2013 Oct 31;4:e896
Cell death & disease 2013 Oct 31;4:e896
Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.
Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ
The EMBO journal 2012 Mar 7;31(5):1293-307
The EMBO journal 2012 Mar 7;31(5):1293-307
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.
Greene AW, Grenier K, Aguileta MA, Muise S, Farazifard R, Haque ME, McBride HM, Park DS, Fon EA
EMBO reports 2012 Apr;13(4):378-85
EMBO reports 2012 Apr;13(4):378-85
SLP-2 is required for stress-induced mitochondrial hyperfusion.
Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, Youle R, Langer T, Martinou JC
The EMBO journal 2009 Jun 3;28(11):1589-600
The EMBO journal 2009 Jun 3;28(11):1589-600
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1.
Ehses S, Raschke I, Mancuso G, Bernacchia A, Geimer S, Tondera D, Martinou JC, Westermann B, Rugarli EI, Langer T
The Journal of cell biology 2009 Dec 28;187(7):1023-36
The Journal of cell biology 2009 Dec 28;187(7):1023-36
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 11510-1-AP(YME1L1 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The YME1L1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human YME1L1. This antibody recognizes human,mouse,rat antigen. The YME1L1 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 11510-1-AP(YME1L1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue