Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 16448-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16448-1-AP, RRID:AB_2092097
- Product name
- DEK antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DEK antibody (Cat. #16448-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression.
ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection.
Loss of DEK Expression Induces Alzheimer's Disease Phenotypes in Differentiated SH-SY5Y Cells.
Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit.
DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages.
Protocol for Isolation and Characterization of In Situ Fixed Quiescent Muscle Stem Cells.
DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas.
DEK Is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma.
Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis.
Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy.
Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.
Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion.
SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.
Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice.
DEK is required for homologous recombination repair of DNA breaks.
Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation.
Regulation of DEK expression by AP-2α and methylation level of DEK promoter in hepatocellular carcinoma.
DEK over-expression promotes mitotic defects and micronucleus formation.
Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.
DEK depletion negatively regulates Rho/ROCK/MLC pathway in non-small cell lung cancer.
The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.
Maintenance of muscle stem-cell quiescence by microRNA-489.
Chen Z, Huo D, Li L, Liu Z, Li Z, Xu S, Huang Y, Wu W, Zhou C, Liu Y, Kuang M, Wu F, Li H, Qian P, Song G, Wu X, Chen J, Hou Y
The Journal of experimental medicine 2021 May 3;218(5)
The Journal of experimental medicine 2021 May 3;218(5)
DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression.
Yang MQ, Bai LL, Wang Z, Lei L, Zheng YW, Li ZH, Huang WJ, Liu CC, Xu HT
Oncology letters 2021 Jun;21(6):440
Oncology letters 2021 Jun;21(6):440
ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection.
Cabral JM, Cushman CH, Sodroski CN, Knipe DM
PLoS pathogens 2021 Apr;17(4):e1009567
PLoS pathogens 2021 Apr;17(4):e1009567
Loss of DEK Expression Induces Alzheimer's Disease Phenotypes in Differentiated SH-SY5Y Cells.
Greene AN, Parks LG, Solomon MB, Privette Vinnedge LM
Frontiers in molecular neuroscience 2020;13:594319
Frontiers in molecular neuroscience 2020;13:594319
Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit.
Yue L, Wan R, Luan S, Zeng W, Cheung TH
Developmental cell 2020 Jun 22;53(6):661-676.e6
Developmental cell 2020 Jun 22;53(6):661-676.e6
DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages.
Pease NA, Shephard MS, Sertorio M, Waltz SE, Vinnedge LMP
Cancers 2020 Jul 17;12(7)
Cancers 2020 Jul 17;12(7)
Protocol for Isolation and Characterization of In Situ Fixed Quiescent Muscle Stem Cells.
Yue L, Cheung TH
STAR protocols 2020 Dec 18;1(3):100128
STAR protocols 2020 Dec 18;1(3):100128
DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas.
Yang MQ, Bai LL, Lei L, Zheng YW, Wang Z, Li ZH, Liu CC, Huang WJ, Xu HT
Oncology reports 2020 Apr;43(4):1338-1348
Oncology reports 2020 Apr;43(4):1338-1348
DEK Is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma.
Lee KF, Tsai MM, Tsai CY, Huang CG, Ou YH, Hsieh CC, Hsieh HL, Wang CS, Lin KH
International journal of molecular sciences 2019 Nov 13;20(22)
International journal of molecular sciences 2019 Nov 13;20(22)
Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis.
Patel Y, Soni M, Awgulewitsch A, Kern MJ, Liu S, Shah N, Singh UP, Chen H
Oncogene 2019 Jan;38(3):445-453
Oncogene 2019 Jan;38(3):445-453
Argininosuccinate synthetase 1 contributes to gastric cancer invasion and progression by modulating autophagy.
Tsai CY, Chi HC, Chi LM, Yang HY, Tsai MM, Lee KF, Huang HW, Chou LF, Cheng AJ, Yang CW, Wang CS, Lin KH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2601-2614
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2601-2614
Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.
Matrka MC, Cimperman KA, Haas SR, Guasch G, Ehrman LA, Waclaw RR, Komurov K, Lane A, Wikenheiser-Brokamp KA, Wells SI
PLoS genetics 2018 Mar;14(3):e1007227
PLoS genetics 2018 Mar;14(3):e1007227
Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion.
Zhou QC, Deng XF, Yang J, Jiang H, Qiao MX, Liu HH, Qian Z, Hou LL, Hu HG
Oncology letters 2018 Jun;15(6):8573-8581
Oncology letters 2018 Jun;15(6):8573-8581
SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.
Ma J, Chang K, Peng J, Shi Q, Gan H, Gao K, Feng K, Xu F, Zhang H, Dai B, Zhu Y, Shi G, Shen Y, Zhu Y, Qin X, Li Y, Zhang P, Ye D, Wang C
Journal of experimental & clinical cancer research : CR 2018 Jul 11;37(1):145
Journal of experimental & clinical cancer research : CR 2018 Jul 11;37(1):145
Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice.
Ghisays V, Nguyen ET, Streicher J, Pease NA, Fitzgerald M, Estrada CM, Franco-Villanueva A, Privette Vinnedge L, Solomon MB
Neuroscience 2018 Feb 10;371:254-267
Neuroscience 2018 Feb 10;371:254-267
DEK is required for homologous recombination repair of DNA breaks.
Smith EA, Gole B, Willis NA, Soria R, Starnes LM, Krumpelbeck EF, Jegga AG, Ali AM, Guo H, Meetei AR, Andreassen PR, Kappes F, Vinnedge LM, Daniel JA, Scully R, Wiesmüller L, Wells SI
Scientific reports 2017 Mar 20;7:44662
Scientific reports 2017 Mar 20;7:44662
Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation.
Yao S, Xu F, Chen Y, Ge Y, Zhang F, Huang H, Li L, Lin D, Luo X, Xu J, Luo D, Zhu X, Liu Y
Journal of experimental & clinical cancer research : CR 2017 Jan 10;36(1):10
Journal of experimental & clinical cancer research : CR 2017 Jan 10;36(1):10
Regulation of DEK expression by AP-2α and methylation level of DEK promoter in hepatocellular carcinoma.
Qiao MX, Li C, Zhang AQ, Hou LL, Yang J, Hu HG
Oncology reports 2016 Oct;36(4):2382-90
Oncology reports 2016 Oct;36(4):2382-90
DEK over-expression promotes mitotic defects and micronucleus formation.
Matrka MC, Hennigan RF, Kappes F, DeLay ML, Lambert PF, Aronow BJ, Wells SI
Cell cycle (Georgetown, Tex.) 2015;14(24):3939-53
Cell cycle (Georgetown, Tex.) 2015;14(24):3939-53
Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.
Lin CJ, Koh FM, Wong P, Conti M, Ramalho-Santos M
Developmental cell 2014 Aug 11;30(3):268-79
Developmental cell 2014 Aug 11;30(3):268-79
DEK depletion negatively regulates Rho/ROCK/MLC pathway in non-small cell lung cancer.
Wang J, Sun L, Yang M, Luo W, Gao Y, Liu Z, Qiu X, Wang E
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2013 Jul;61(7):510-21
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2013 Jul;61(7):510-21
The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.
Begum NA, Stanlie A, Nakata M, Akiyama H, Honjo T
The Journal of biological chemistry 2012 Sep 21;287(39):32415-29
The Journal of biological chemistry 2012 Sep 21;287(39):32415-29
Maintenance of muscle stem-cell quiescence by microRNA-489.
Cheung TH, Quach NL, Charville GW, Liu L, Park L, Edalati A, Yoo B, Hoang P, Rando TA
Nature 2012 Feb 23;482(7386):524-8
Nature 2012 Feb 23;482(7386):524-8
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 16448-1-AP(DEK antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using DEK antibody 16448-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 16448-1-AP(DEK antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 16448-1-AP(DEK antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
