CLNS1A

This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Description

Chloride nucleotide-sensitive channel 1A

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Microtubules, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

11 (77514936 - 77637794)

Ensembl ID

ENSG00000074201  (ver. 103.38)

Orthologs

Mouse Clns1a: ENSMUSG00000025439

UniProt

P54105

neXtProt

NX_P54105

Human splice variants
Mouse splice variants

Protein structure