66219-1-Ig

antibody from Proteintech Group

Targeting: CDH2 CD325, CDHN, NCAD

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66219-1-Ig

Provider

Proteintech Group

Product name

N-cadherin antibody

Antibody type

Monoclonal

Description

KD/KO validated N-cadherin antibody (Cat. #66219-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1D8B3

Vial size

20ul, 150ul

References

Submitted references

Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics.

Shin YY, Seo Y, Oh SJ, Ahn JS, Song MH, Kang MJ, Oh JM, Lee D, Kim YH, Sung ES, Kim HS
Journal of pineal research 2022 Jan;72(1):e12779

---

NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.

Dang NN, Li XB, Zhang M, Han C, Fan XY, Huang SH
Frontiers in cell and developmental biology 2021;9:662763

---

TAp63α Is Involved in Tobacco Smoke-Induced Lung Cancer EMT and the Anti-cancer Activity of Curcumin via miR-19 Transcriptional Suppression.

Xie C, Zhu J, Yang X, Huang C, Zhou L, Meng Z, Li X, Zhong C
Frontiers in cell and developmental biology 2021;9:645402

---

Extracellular Vesicles Carry lncRNA SNHG16 to Promote Metastasis of Breast Cancer Cells via the miR-892b/PPAPDC1A Axis.

Xia W, Liu Y, Cheng T, Xu T, Dong M, Hu X
Frontiers in cell and developmental biology 2021;9:628573

---

The Gut Microbiota Activates AhR Through the Tryptophan Metabolite Kyn to Mediate Renal Cell Carcinoma Metastasis.

Dai G, Chen X, He Y
Frontiers in nutrition 2021;8:712327

---

miR-942-5p Inhibits Proliferation, Metastasis, and Epithelial-Mesenchymal Transition in Colorectal Cancer by Targeting CCBE1.

Zhou L, Chen Q, Wu J, Yang J, Yin H, Tian J, Gong L, Kong D, Tao M
BioMed research international 2021;2021:9951405

---

Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro.

Wu Y, Zhang Z, Kou Z
Drug design, development and therapy 2021;15:2857-2868

---

Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells.

Yan S, Li Q, Zhang D, Wang X, Xu Y, Zhang C, Guo D, Bao Y
American journal of cancer research 2021;11(5):2062-2080

---

A Novel c-MET-Targeting Antibody-Drug Conjugate for Pancreatic Cancer.

Jin Y, Zhang Z, Zou S, Li F, Chen H, Peng C, Deng X, Wen C, Shen B, Zhan Q
Frontiers in oncology 2021;11:634881

---

miRNA-10a-5p inhibits cell metastasis in hepatocellular carcinoma via targeting SKA1.

Shen D, Zhao HY, Gu AD, Wu YW, Weng YH, Li SJ, Song JY, Gu XF, Qiu J, Zhao W
The Kaohsiung journal of medical sciences 2021 Sep;37(9):784-794

---

OGT regulated O-GlcNacylation promotes migration and invasion by activating IL-6/STAT3 signaling in NSCLC cells.

Ge X, Peng X, Li M, Ji F, Chen J, Zhang D
Pathology, research and practice 2021 Sep;225:153580

---

EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop.

Lin J, Zeng C, Zhang J, Song Z, Qi N, Liu X, Zhang Z, Li A, Chen F
Molecular therapy. Nucleic acids 2021 Sep 3;25:328-341

---

Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation.

Xiong L, Ye X, Chen Z, Fu H, Li S, Xu P, Yu J, Wen L, Gao R, Fu Y, Qi H, Kilby MD, Saffery R, Baker PN, Tong C
Aging cell 2021 Oct;20(10):e13491

---

FABP4 is an independent risk factor for lymph node metastasis and poor prognosis in patients with cervical cancer.

Li G, Wu Q, Gong L, Xu X, Cai J, Xu L, Zeng Y, He X, Wang Z
Cancer cell international 2021 Oct 26;21(1):568

---

Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway.

Wang D, Cui L, Yang Q, Wang J
Cellular signalling 2021 Nov;87:110145

---

HSD17B6 downregulation predicts poor prognosis and drives tumor progression via activating Akt signaling pathway in lung adenocarcinoma.

Tian T, Hong F, Wang Z, Hu J, Chen N, Lv L, Yi Q
Cell death discovery 2021 Nov 8;7(1):341

---

Inhibition of Ras protein activator like 2 produces antitumor effects in gastric cancer via the suppression of YAP1 activation.

Hu Y, Zhang P, Shi Y, Dong X, Wu Y, Dong D, Li E, Fan Y
Environmental toxicology 2021 Nov 26;

---

circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis.

Ma X, Ying Y, Sun J, Xie H, Li J, He L, Wang W, Chen S, Shen H, Yi J, Luo J, Wang X, Zheng X, Liu B, Xie L
Cell death discovery 2021 Nov 23;7(1):365

---

CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1.

Pan J, Lin M, Xu Z, Xu M, Zhang J, Weng Z, Lin B, Lin X
Carcinogenesis 2021 Nov 12;42(11):1399-1409

---

Moderate oxidative stress promotes epithelial-mesenchymal transition in the lens epithelial cells via the TGF-β/Smad and Wnt/β-catenin pathways.

Chen X, Yan H, Chen Y, Li G, Bin Y, Zhou X
Molecular and cellular biochemistry 2021 Mar;476(3):1631-1642

---

Expression of Talin-1 in endometriosis and its possible role in pathogenesis.

Tang X, Li Q, Li L, Jiang J
Reproductive biology and endocrinology : RB&E 2021 Mar 9;19(1):42

---

Tumor cell membrane-based peptide delivery system targeting the tumor microenvironment for cancer immunotherapy and diagnosis.

Meng X, Wang J, Zhou J, Tian Q, Qie B, Zhou G, Duan W, Zhu Y
Acta biomaterialia 2021 Jun;127:266-275

---

Tumor-associated macrophages promote pancreatic ductal adenocarcinoma progression by inducing epithelial-to-mesenchymal transition.

Xiong C, Zhu Y, Xue M, Jiang Y, Zhong Y, Jiang L, Shi M, Chen H
Aging 2021 Jan 10;13(3):3386-3404

---

Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.

Li Y, Zhao Y, Li Y, Zhang X, Li C, Long N, Chen X, Bao L, Zhou J, Xie Y
Journal of physiology and biochemistry 2021 Feb;77(1):93-104

---

Hypermethylation of PI3K-AKT signalling pathway genes is associated with human neural tube defects.

Tian T, Lai X, Xiang K, Han X, Yin S, Cabrera RM, Steele JW, Lei Y, Cao X, Finnell RH, Wang L, Ren A
Epigenetics 2021 Feb 17;:1-14

---

Long non-coding RNA GClnc1 knockdown suppresses progression of epithelial ovarian cancer by recruiting FOXC2 to disrupt the NOTCH1/NF-κB/Snail pathway.

Wu D, Ke Y, Xiao R, Liu J, Li Q, Wang Y
Experimental cell research 2021 Feb 1;399(1):112422

---

BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.

Guo H, Peng J, Hu J, Chang S, Liu H, Luo H, Chen X, Tang H, Chen Y
Journal of bone oncology 2021 Dec;31:100393

---

EPB41L5 promotes EMT through the ERK/p38 MAPK signaling pathway in esophageal squamous cell carcinoma.

Bao S, Ji Z, Shi M, Liu X
Pathology, research and practice 2021 Dec;228:153682

---

LncRNA ABCC6P1 promotes proliferation and migration of papillary thyroid cancer cells via Wnt/β-catenin signaling pathway.

Guan Y, Li Y, Yang QB, Yu J, Qiao H
Annals of translational medicine 2021 Apr;9(8):664

---

TET1 may contribute to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis.

Wu J, Li X, Huang H, Xia X, Zhang M, Fang X
PeerJ 2020;8:e9950

---

AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.

Xu F, Xu Y, Xiong JH, Zhang JH, Wu J, Luo J, Xiong JP
Cancer management and research 2020;12:1789-1798

---

Sanguisorba officinalis L. Suppresses Triple-Negative Breast Cancer Metastasis by Inhibiting Late-Phase Autophagy via Hif-1α/Caveolin-1 Signaling.

Wang N, Muhetaer G, Zhang X, Yang B, Wang C, Zhang Y, Wang X, Zhang J, Wang S, Zheng Y, Zhang F, Wang Z
Frontiers in pharmacology 2020;11:591400

---

EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis.

Hu Y, Wei X, Lv Y, Xie X, Yang L, He J, Tao X, Ma Y, Su Y, Wu L, Fang W, Liu Z
American journal of cancer research 2020;10(1):179-195

---

Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer.

Dong X, Lv S, Gu D, Zhang X, Ye Z
Frontiers in oncology 2020;10:553628

---

Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling.

Guo W, Zhang Z, Li G, Lai X, Gu R, Xu W, Chen H, Xing Z, Chen L, Qian J, Xu S, Zeng F, Deng F
Frontiers in oncology 2020;10:544288

---

GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.

Cheng L, Gou L, Wei T, Zhang J
International journal of oncology 2020 Sep;57(3):858-870

---

YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer.

Li J, Xie H, Ying Y, Chen H, Yan H, He L, Xu M, Xu X, Liang Z, Liu B, Wang X, Zheng X, Xie L
Molecular cancer 2020 Oct 29;19(1):152

---

Polydatin inhibits ZEB1-invoked epithelial-mesenchymal transition in fructose-induced liver fibrosis.

Zhao X, Yang Y, Yu H, Wu W, Sun Y, Pan Y, Kong L
Journal of cellular and molecular medicine 2020 Nov;24(22):13208-13222

---

DEPDC1B promotes migration and invasion in pancreatic ductal adenocarcinoma by activating the Akt/GSK3β/Snail pathway.

Liu X, Li T, Huang X, Wu W, Li J, Wei L, Qian Y, Xu H, Wang Q, Wang L
Oncology letters 2020 Nov;20(5):146

---

Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.

Zhang J, Chen Y, Lin J, Jia R, An T, Dong T, Zhang Y, Yang X
DNA and cell biology 2020 Mar;39(3):355-367

---

CircATRNL1 promotes epithelial-mesenchymal transition in endometriosis by upregulating Yes-associated protein 1 in vitro.

Wang D, Luo Y, Wang G, Yang Q
Cell death & disease 2020 Jul 29;11(7):594

---

METTL3/YTHDF2 m⁶ A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.

Xie H, Li J, Ying Y, Yan H, Jin K, Ma X, He L, Xu X, Liu B, Wang X, Zheng X, Xie L
Journal of cellular and molecular medicine 2020 Apr;24(7):4092-4104

---

miR-145-5p suppresses proliferation, metastasis and EMT of colorectal cancer by targeting CDCA3.

Chen Q, Zhou L, Ye X, Tao M, Wu J
Pathology, research and practice 2020 Apr;216(4):152872

---

VASN promotes YAP/TAZ and EMT pathway in thyroid carcinogenesis in vitro.

Bhandari A, Guan Y, Xia E, Huang Q, Chen Y
American journal of translational research 2019;11(6):3589-3599

---

Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.

Liu Y, Jiang Q, Liu X, Lin X, Tang Z, Liu C, Zhou J, Zhao M, Li X, Cheng Z, Li L, Xie Y, Liu Z, Fang W
EBioMedicine 2019 Oct;48:386-404

---

Lgl1 deficiency disrupts hippocampal development and impairs cognitive performance in mice.

Zhang T, Hou C, Zhang S, Liu S, Li Z, Gao J
Genes, brain, and behavior 2019 Nov;18(8):e12605

---

Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway.

Yanchun M, Yi W, Lu W, Yu Q, Jian Y, Pengzhou K, Ting Y, Hongyi L, Fang W, Xiaolong C, Yongping C
European journal of pharmacology 2019 May 15;851:43-51

---

The contrary functions of lncRNA HOTAIR/miR-17-5p/PTEN axis and Shenqifuzheng injection on chemosensitivity of gastric cancer cells.

Jia J, Zhan D, Li J, Li Z, Li H, Qian J
Journal of cellular and molecular medicine 2019 Jan;23(1):656-669

---

miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα.

Xin H, Wang C, Liu Z
BMC cancer 2019 Jan 8;19(1):30

---

Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.

Wang X, Yin L, Yang L, Zheng Y, Liu S, Yang J, Cui H, Wang H
The FEBS journal 2019 Dec;286(24):4889-4909

---

RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer.

Li Q, Lai Q, He C, Fang Y, Yan Q, Zhang Y, Wang X, Gu C, Wang Y, Ye L, Han L, Lin X, Chen J, Cai J, Li A, Liu S
Journal of experimental & clinical cancer research : CR 2019 Aug 1;38(1):334

---

Increased expression of lncRNA SNHG12 predicts a poor prognosis of nasopharyngeal carcinoma and regulates cell proliferation and metastasis by modulating Notch signal pathway.

Liu ZB, Tang C, Jin X, Liu SH, Pi W
Cancer biomarkers : section A of Disease markers 2018;23(4):603-613

---

Krüppel-like Factor 4 Suppresses Serine/Threonine Kinase 33 Activation and Metastasis of Gastric Cancer through Reversing Epithelial-Mesenchymal Transition.

Kong F, Sun T, Kong X, Xie D, Li Z, Xie K
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 May 15;24(10):2440-2451

---

Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.

Wang S, Li J, Xie J, Liu F, Duan Y, Wu Y, Huang S, He X, Wang Z, Wu X
Oncogene 2018 Jul;37(30):4164-4180

---

Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway.

Wu D, Zhao B, Qi X, Peng F, Fu H, Chi X, Miao QR, Shao S
Cancer letters 2018 Apr 1;418:135-146

---

Long non-coding RNA NEAT1 regulates epithelial membrane protein 2 expression to repress nasopharyngeal carcinoma migration and irradiation-resistance through miR-101-3p as a competing endogenous RNA mechanism.

Wang Y, Wang C, Chen C, Wu F, Shen P, Zhang P, He G, Li X
Oncotarget 2017 Sep 19;8(41):70156-70171

---

In vitro anticancer activities of osthole against renal cell carcinoma cells.

Liu L, Mao J, Wang Q, Zhang Z, Wu G, Tang Q, Zhao B, Li L, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:1020-1027

---

SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells.

Xu CY, Liu SQ, Qin MB, Zhuge CF, Qin L, Qin N, Lai MY, Huang JA
International journal of molecular medicine 2017 May;39(5):1277-1284

---

Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro.

Zhao B, Liu L, Mao J, Liu K, Fan W, Liu J, Zhang Z, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1036-1044

---

Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice.

Zhang J, Liu Z, Zhang T, Lin Z, Li Z, Zhang A, Sun X, Gao J
Scientific reports 2016 Sep 20;6:33856