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- Antigen structure
- References [6]
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- Validations
- Western blot [1]
- Other assay [1]
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- Product number
- 71-7200 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- METAP2 Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Other
- Reactivity
- Human, Mouse, Bovine
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.25 mg/mL
- Storage
- -20°C
Submitted references 24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins.
A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay.
Characterization of recombinant microsporidian methionine aminopeptidase type 2.
Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation.
Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity.
Nakagawa H, Koyanagi S, Takiguchi T, Kuramoto Y, Soeda S, Shimeno H, Higuchi S, Ohdo S
Cancer research 2004 Nov 15;64(22):8328-33
Cancer research 2004 Nov 15;64(22):8328-33
A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
Bernier SG, Lazarus DD, Clark E, Doyle B, Labenski MT, Thompson CD, Westlin WF, Hannig G
Proceedings of the National Academy of Sciences of the United States of America 2004 Jul 20;101(29):10768-73
Proceedings of the National Academy of Sciences of the United States of America 2004 Jul 20;101(29):10768-73
A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay.
Miller WJ, Kayton ML, Patton A, O'Connor S, He M, Vu H, Baibakov G, Lorang D, Knezevic V, Kohn E, Alexander HR, Stirling D, Payvandi F, Muller GW, Libutti SK
Journal of translational medicine 2004 Jan 30;2(1):4
Journal of translational medicine 2004 Jan 30;2(1):4
Characterization of recombinant microsporidian methionine aminopeptidase type 2.
Weiss LM, Zhou GC, Zhang H
The Journal of eukaryotic microbiology 2003;50 Suppl:597-9
The Journal of eukaryotic microbiology 2003;50 Suppl:597-9
Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation.
Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, Deshaies RJ
Proceedings of the National Academy of Sciences of the United States of America 2001 Jul 17;98(15):8554-9
Proceedings of the National Academy of Sciences of the United States of America 2001 Jul 17;98(15):8554-9
Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity.
Catalano A, Romano M, Robuffo I, Strizzi L, Procopio A
The American journal of pathology 2001 Aug;159(2):721-31
The American journal of pathology 2001 Aug;159(2):721-31
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of EL-4 cell lysates using Rb anti-MetAP-2 (Product # 71-7200).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 6 LES/ CC5079. (A) p21 was increased in CAM disks treated with systemic CC 5079 as compared to control ( P < 0.0001, Student's t test). (B) MetAP-2 trended towards greater expression in CAM disks after systemic CC 5079 injection, but this did not reach statistical significance compared to control ( P = 0.0787, Student's t test). (C) CC5079 increased the expression of cleaved caspase-3 ( P = 0.0184, Alternate Welch t test) while (D) inhibiting the expression of alpha v beta 3 ( P = 0.0266, Alternate Welch t test).
