BS8111

antibody from Bioworld Technology, Inc

Targeting: NEU1 NEU

Immunohistochemistry

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Validation data

Product number: BS8111 - Provider product page
Provider: Bioworld Technology, Inc
Product name: NEU1 polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human NEU1.
Description: NEU1 encodes the lysosomal enzyme neuraminidase, Neu1, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids . In the lysosome Neu1 belongs to a heterotrimeric complex containing beta-galactosidase and cathepsin A (also referred to as 'protective protein') . In humans, primary or secondary deficiency of this enzyme leads to two clinically similar neurodegenerative lysosomal storage disorders: sialidosis and galactosialidosis (GS) . Sialidosis symptoms range from eye abnormalities and neurological disturbances to skeletal malformations, mental retardation and early death. Neu1 is expressed in the pancreas, muscle, kidney, placenta, heart, lung and liver. The human Neu1 gene maps to chromosome 6p21.33 and encodes a lysosomal protein localized on the inner side of the plasma membrane and in intracellular vesicles . Neu1 is also known as alpha-N-acetyl-neuraminidase and Acetylneuraminyl hydrolase .
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

NEU1 protein structure - BS8111 shown in red.