GAB2

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Description

GRB2 associated binding protein 2

Tissue specificity

Tissue enhanced (brain)

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

11 (78215293 - 78418348)

Ensembl ID

ENSG00000033327  (ver. 103.38)

Orthologs

Mouse Gab2: ENSMUSG00000004508

UniProt

Q9UQC2

neXtProt

NX_Q9UQC2

Human splice variants
Mouse splice variants

Protein structure