BS8327

antibody from Bioworld Technology, Inc

Targeting: MFGE8 BA46, EDIL1, hP47, HsT19888, MFG-E8, OAcGD3S, SED1, SPAG10

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8327

Provider

Bioworld Technology, Inc

Product name

MFGE8 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human MFGE8.

Description

Human milk-fat globule (MFG) is abundant in human breast milk and is composed of secreted lipids encapsulated by plasma membranes from the epithelial cells of mammary glands. MFG membranes are composed of various glycoproteins that serve as markers for differentiated carcinomas. MFG-E8 (Milk fat globule-EGF factor 8), also known as Lactadherin or BA46, is a 387 amino acid peripheral membrane protein that localizes to the membrane of a variety of tissues, including mammary epithelial surfaces, and contains one EGF-like domain and two F5/8 type C domains. Functioning as a specific ligand for Integrin ÉÇ 5 and Integrin ÉÇ3, MFG-E8 is thought to be involved in gamete interactions and cell attachment, possibly playing a role in fertilization and apoptosis. Additionally, MFG-E8 binds to rotavirus and inhibits its replication, thereby protecting the cell from viral infection. Overexpression of MFG-E8 is associated with breast cancer, suggesting that MFG-E8 may be related to tumorigenesis.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.