BS4180

antibody from Bioworld Technology, Inc

Targeting: STAT3 APRF

Immunoprecipitation

Immunohistochemistry

Antibody data

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Validation data

Product number: BS4180 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS4180, RRID:AB_1664123
Product name: Stat3 (phospho S727) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic phosphopeptide derived from human Stat3 around the phosphorylation site of Serine 727.
Description: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-Ï« and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3ÉÇ appears to be activated by both while Stat3Ï« is activated by EGF, but not by IL-6. Highest expresion of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

STAT3 protein structure - BS4180 shown in red.