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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Product number
- ABIN362405 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pTyr427) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pTyr427 (P-S-Y (p) -V-N derived from Human Shc1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pTyr427
- Isotype
- IgG
- Vial size
- 50 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development.
Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions.
Trampont P, Zhang L, Ravichandran KS
Molecular and cellular biology 2006 Dec;26(23):9035-44
Molecular and cellular biology 2006 Dec;26(23):9035-44
Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
Patrussi L, Savino MT, Pellegrini M, Paccani SR, Migliaccio E, Plyte S, Lanfrancone L, Pelicci PG, Baldari CT
Oncogene 2005 Mar 24;24(13):2218-28
Oncogene 2005 Mar 24;24(13):2218-28
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions.
van der Geer P, Wiley S, Gish GD, Pawson T
Current biology : CB 1996 Nov 1;6(11):1435-44
Current biology : CB 1996 Nov 1;6(11):1435-44
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