MAB5011-100

antibody from R&D Systems

Targeting: IL1B IL-1B, IL1-BETA, IL1F2

Western blot (Data presented on provider website)

Antibody Data

Product number

MAB5011-100

Provider

R&D Systems

Product name

Rat IL-1 beta/IL-1F2 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects rat IL-1 beta in direct ELISAs and Western blots. In these formats, this antibody shows approximately 100% cross-reactivity with recombinant mouse (rm) IL-1 beta and rcrIL-1 beta and no cross-reactivity with rfIL-1 beta , rhIL-1 beta , or rrmIL-1 beta .

Reactivity

Rat

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

Q63264


Isotype

IgG

Antibody clone number

38123

Vial size

100 ug

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression.

Xiang HC, Lin LX, Hu XF, Zhu H, Li HP, Zhang RY, Hu L, Liu WT, Zhao YL, Shu Y, Pan HL, Li M
Journal of neuroinflammation 2019 Feb 12;16(1):34

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Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD.

Szeto HH, Liu S, Soong Y, Seshan SV, Cohen-Gould L, Manichev V, Feldman LC, Gustafsson T
Journal of the American Society of Nephrology : JASN 2017 May;28(5):1437-1449

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Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation.

Kang LL, Zhang DM, Ma CH, Zhang JH, Jia KK, Liu JH, Wang R, Kong LD
Scientific reports 2016 Jun 8;6:27460