IRF4

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Description

interferon regulatory factor 4

Protein family

Transcription factors

Chromosome

6:p25.3 (391739 - 411447)

Ensembl ID

ENSG00000137265  (ver. 69.37)

Orthologs

Mouse Irf4: ENSMUSG00000021356

Human splice variants
Mouse splice variants