CRHR2

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jan 2011]

Description

corticotropin releasing hormone receptor 2

Protein family

G-protein coupled receptors, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

7:p14.3 (30692200 - 30739745)

Ensembl ID

ENSG00000106113  (ver. 71.37)

Orthologs

Mouse Crhr2: ENSMUSG00000003476

Human splice variants
Mouse splice variants