ARNTL2

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Description

aryl hydrocarbon receptor nuclear translocator-like 2

Protein family

Mapped to UniProt SWISS-PROT, Transcription factors

Chromosome

12:p11.23 (27485787 - 27576241)

Ensembl ID

ENSG00000029153  (ver. 71.37)

Orthologs

Mouse Arntl2: ENSMUSG00000040187

Human splice variants
Mouse splice variants