ADAMTS3

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues. [provided by RefSeq, Jul 2008]

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 3

Protein family

Peptidases, Secreted proteins predicted by MDSP

Chromosome

4:q13.3 (73146686 - 73434516)

Ensembl ID

ENSG00000156140  (ver. 69.37)

Orthologs

Mouse Adamts3: ENSMUSG00000043635

Human splice variants
Mouse splice variants