NNT

This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Description

nicotinamide nucleotide transhydrogenase

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

5:p12 (43602794 - 43707507)

Ensembl ID

ENSG00000112992  (ver. 71.37)

Orthologs

Mouse Nnt: ENSMUSG00000025453

Human splice variants
Mouse splice variants