ADAM19

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. [provided by RefSeq, May 2009]

Description

ADAM metallopeptidase domain 19

Protein family

Membrane proteins predicted by MDM, Peptidases, Secreted proteins predicted by MDSP

Chromosome

5:q33.3 (156822542 - 157002783)

Ensembl ID

ENSG00000135074  (ver. 69.37)

Orthologs

Mouse Adam19: ENSMUSG00000011256

Human splice variants
Mouse splice variants