ABCC2

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

Protein family

Candidate cancer biomarkers, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Transporters

Chromosome

10:q24.2 (101542489 - 101611949)

Ensembl ID

ENSG00000023839  (ver. 71.37)

Orthologs

Mouse Abcc2: ENSMUSG00000025194

Human splice variants
Mouse splice variants