ARHGEF4

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene. [provided by RefSeq, Jul 2008]

Description

Rho guanine nucleotide exchange factor (GEF) 4

Protein family

Mapped to UniProt SWISS-PROT, SH3-domain containing proteins

Chromosome

2:q21.1 (131594489 - 131804836)

Ensembl ID

ENSG00000136002  (ver. 71.37)

Orthologs

Mouse Arhgef4: ENSMUSG00000037509

Human splice variants
Mouse splice variants