ACVR2A

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq, Jul 2008]

Description

activin A receptor, type IIA

Protein family

Enzymes, Kinases, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

2:q22.3 (148602086 - 148688393)

Ensembl ID

ENSG00000121989  (ver. 69.37)

Orthologs

Mouse Acvr2a: ENSMUSG00000052155

Human splice variants
Mouse splice variants