MLTK

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Description

Mitogen-activated protein kinase kinase kinase MLT

Protein family

Enzymes, Kinases, Mapped to UniProt SWISS-PROT

Chromosome

2:q31.1 (173940163 - 174132738)

Ensembl ID

ENSG00000091436  (ver. 71.37)

Orthologs

Mouse B230120H23Rik: ENSMUSG00000004085

Human splice variants
Mouse splice variants