KCNH1

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Description

potassium voltage-gated channel, subfamily H (eag-related), member 1

Protein family

Membrane proteins predicted by MDM, Voltage-gated ion channels

Chromosome

1:q32.2 (210856555 - 211307457)

Ensembl ID

ENSG00000143473  (ver. 69.37)

Orthologs

Mouse Kcnh1: ENSMUSG00000058248

Human splice variants
Mouse splice variants