ALDH1A2

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]

Description

aldehyde dehydrogenase 1 family, member A2

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential transmembrane proteins

Chromosome

15:q21.3 (58245622 - 58790065)

Ensembl ID

ENSG00000128918  (ver. 71.37)

Orthologs

Mouse Aldh1a2: ENSMUSG00000013584

Human splice variants
Mouse splice variants