IDI1

IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

Description

isopentenyl-diphosphate delta isomerase 1

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

10:p15.3 (1085848 - 1095110)

Ensembl ID

ENSG00000067064  (ver. 71.37)

Orthologs

Mouse Idi1: ENSMUSG00000058258

Human splice variants
Mouse splice variants