ADAM15

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Description

ADAM metallopeptidase domain 15

Protein family

Membrane proteins predicted by MDM, Peptidases, Secreted proteins predicted by MDSP

Chromosome

1:q22 (155023042 - 155035252)

Ensembl ID

ENSG00000143537  (ver. 69.37)

Orthologs

Mouse Adam15: ENSMUSG00000028041

Human splice variants
Mouse splice variants