MRPL4

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]

Description

mitochondrial ribosomal protein L4

Protein family

Ribosomal proteins

Chromosome

19:p13.2 (10362577 - 10370721)

Ensembl ID

ENSG00000105364  (ver. 69.37)

Orthologs

Mouse Mrpl4: ENSMUSG00000003299

Human splice variants
Mouse splice variants