ATP6V1C2

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]

Description

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

Protein family

Transporters

Chromosome

2:p25.1 (10861775 - 10925236)

Ensembl ID

ENSG00000143882  (ver. 69.37)

Orthologs

Mouse Atp6v1c2: ENSMUSG00000020566

Human splice variants
Mouse splice variants