ACACA

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

acetyl-CoA carboxylase alpha

Protein family

Enzymes

Chromosome

17:q12 (35441923 - 35766909)

Ensembl ID

ENSG00000132142  (ver. 69.37)

Orthologs

Mouse Acaca: ENSMUSG00000020532

Human splice variants
Mouse splice variants