PSMB3

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Pseudogenes have been identified on chromosomes 2 and 12. [provided by RefSeq, Jul 2008]

Description

proteasome (prosome, macropain) subunit, beta type, 3

Protein family

Enzymes, Peptidases

Chromosome

17:q12 (36908989 - 36920484)

Ensembl ID

ENSG00000108294  (ver. 69.37)

Orthologs

-

Human splice variants