ZNRF1

This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]

Description

zinc and ring finger 1, E3 ubiquitin protein ligase

Protein family

Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

16:q23.1 (75032928 - 75144892)

Ensembl ID

ENSG00000186187  (ver. 71.37)

Orthologs

Mouse Znrf1: ENSMUSG00000033545

Human splice variants
Mouse splice variants