FPGS

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]

Description

folylpolyglutamate synthase

Protein family

Enzymes, Secreted proteins predicted by MDSP

Chromosome

9:q34.11 (130556876 - 130576606)

Ensembl ID

ENSG00000136877  (ver. 69.37)

Orthologs

Mouse Fpgs: ENSMUSG00000009566

Human splice variants
Mouse splice variants