ACE

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Description

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Protein family

CD markers, Enzymes, Membrane proteins predicted by MDM, Peptidases, Secreted proteins predicted by MDSP

Chromosome

17:q23.3 (61554422 - 61599205)

Ensembl ID

ENSG00000159640  (ver. 69.37)

Orthologs

-

Human splice variants