EPHB6

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. [provided by RefSeq, Jul 2008]

Description

EPH receptor B6

Protein family

Kinases, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

7:q34 (142552792 - 142568847)

Ensembl ID

ENSG00000106123  (ver. 69.37)

Orthologs

Mouse Ephb6: ENSMUSG00000029869

Human splice variants
Mouse splice variants