BPNT1

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

Description

3'(2'), 5'-bisphosphate nucleotidase 1

Protein family

Enzymes

Chromosome

1:q41 (220230824 - 220263804)

Ensembl ID

ENSG00000162813  (ver. 69.37)

Orthologs

Mouse Bpnt1: ENSMUSG00000026617

Human splice variants
Mouse splice variants