CD3E

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Description

CD3e molecule, epsilon (CD3-TCR complex)

Protein family

CD markers, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

11:q23.3 (118175260 - 118186890)

Ensembl ID

ENSG00000198851  (ver. 71.37)

Orthologs

Mouse Cd3e: ENSMUSG00000032093

Human splice variants
Mouse splice variants