F3

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Description

coagulation factor III (thromboplastin, tissue factor)

Protein family

Candidate cancer biomarkers, Candidate cardiovascular disease genes, CD markers, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential transmembrane proteins, Potentially secreted proteins

Chromosome

1:p21.3 (94994781 - 95007356)

Ensembl ID

ENSG00000117525  (ver. 71.37)

Orthologs

Mouse F3: ENSMUSG00000028128

Human splice variants
Mouse splice variants