MRPL47

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

mitochondrial ribosomal protein L47

Protein family

Mapped to UniProt SWISS-PROT, Potentially secreted proteins, Ribosomal proteins

Chromosome

3:q26.33 (179306073 - 179322442)

Ensembl ID

ENSG00000136522  (ver. 71.37)

Orthologs

Mouse Mrpl47: ENSMUSG00000037531

Human splice variants
Mouse splice variants