CYSLTR1

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. [provided by RefSeq, Jul 2008]

Description

cysteinyl leukotriene receptor 1

Protein family

GPCRs excl olfactory receptors, Membrane proteins predicted by MDM, Transporters

Chromosome

X:q21.1 (77526961 - 77583048)

Ensembl ID

ENSG00000173198  (ver. 69.37)

Orthologs

Mouse Cysltr1: ENSMUSG00000052821

Human splice variants
Mouse splice variants