IDO1

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. [provided by RefSeq, Feb 2011]

Description

indoleamine 2,3-dioxygenase 1

Protein family

Candidate cancer biomarkers, Enzymes, Mapped to UniProt SWISS-PROT, Potential transmembrane proteins

Chromosome

8:p11.21 (39759794 - 39785963)

Ensembl ID

ENSG00000131203  (ver. 71.37)

Orthologs

Mouse Ido1: ENSMUSG00000031551

Human splice variants
Mouse splice variants