FADD

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Description

Fas (TNFRSF6)-associated via death domain

Protein family

Candidate cancer biomarkers, Mapped to UniProt SWISS-PROT, Potentially secreted proteins

Chromosome

11:q13.3 (70049269 - 70053496)

Ensembl ID

ENSG00000168040  (ver. 71.37)

Orthologs

Mouse Fadd: ENSMUSG00000031077

Human splice variants
Mouse splice variants