CD55

This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Description

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

Protein family

Blood group antigen proteins, CD markers, Membrane proteins predicted by MDM, Secreted proteins predicted by MDSP

Chromosome

1:q32.2 (207494853 - 207534311)

Ensembl ID

ENSG00000196352  (ver. 69.37)

Orthologs

-

Human splice variants