TRPM1

This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Description

transient receptor potential cation channel, subfamily M, member 1

Protein family

Membrane proteins predicted by MDM, Voltage-gated ion channels

Chromosome

15:q13.3 (31293264 - 31453476)

Ensembl ID

ENSG00000134160  (ver. 69.37)

Orthologs

Mouse Trpm1: ENSMUSG00000030523

Human splice variants
Mouse splice variants