RB-02-0029-200

antibody from RayBiotech, Inc.

Targeting: DIABLO DFNA64, DIABLO-S, FLJ10537, FLJ25049, SMAC

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

RB-02-0029-200

Provider

RayBiotech, Inc.

Proper citation

RayBiotech Cat#RB-02-0029-200, RRID:AB_11217617

Product name

Rabbit Anti-Human SMAC

Antibody type

Polyclonal

Antigen

a synthetic peptide (SMAC).

Description

Second mitochondria-derived activator of caspases, SMAC is a mitochondrial protein that promotes cytochrome-c dependent activation by eliminating the inhibition via IAP - a protein that negatively regulates apoptosis or programmed cell death. Smac is normally a mitochondrial protein but is found in the cytosol when a cell is primed for apoptosis by the final execution step of caspase activation. Smac is the second protein in the apoptosis link, along with cytochrome c, that promotes apoptosis by activating caspases. SMAC is an inhibitor of apoptosis protein (IAP)-binding protein. This mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. This antibody was produced from a rabbit immunized with this peptide conjugated with KLH. The IgG fraction was purified from rabbit serum by Protein G affinity chromatography.

Reactivity

Human

Host

Rabbit

Conjugate

Biotin

Antigen sequence

This antibody was produced from a r
abbit immunized with this peptide c
onjugated with KLH. The IgG fractio
n was purified from rabbit serum by
Protein G affinity chromatography.


Isotype

IgG

Vial size

200 µg

Handling

Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1 x PBS to a final concentration of 1 mg/ml.