NBP2-48009-0.1mg

antibody from Novus Biologicals

Targeting: TFF1 BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2

Immunocytochemistry

Flow cytometry

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Validation data

Product number: NBP2-48009-0.1mg - Provider product page
Provider: Novus Biologicals
Product name: Mouse Monoclonal TFF1/pS2 Antibody
Antibody type: Monoclonal
Description: Protein A or G purified. It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Reactivity: Human
Host: Mouse
Isotype: IgG
Vial size: 0.1 mg
Concentration: 1.0 mg/ml
Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

TFF1 protein structure - NBP2-48009-0.1mg shown in red.